Spastic paraparesis and HTLV‐I infection in peru

Richard T. Johnson; Diane E. Griffin; Alberto Arregui; Carlos Mora; Clarence J. Gibbs; Juan M. Cuba; Luis Trelles; Abraham Vaisberg

doi:10.1002/ana.410230734

Spastic paraparesis and HTLV‐I infection in peru

Richard T. Johnson, Diane E. Griffin, Alberto Arregui, Carlos Mora, Clarence J. Gibbs, Juan M. Cuba, Luis Trelles, Abraham Vaisberg

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Three of 6 patients with spastic paraparesis in Lima, Peru, were found to have antibodies to human T‐lymphotropic virus type I (HTLV‐I). Blood and cerebrospinal fluid antibodies were confirmed by Western blot analysis. Multilobulated lymphocytes in blood and cerebrospinal fluid of the index case stained with monoclonal antibodies for T‐helper cells and for T10, an activation marker. Blood mononuclear cells from patients with HTLV‐I–associated myelopathy showed spontaneous proliferation in culture, evidence of interleukin‐2 receptors, and decreased natural killer cell activity.

Original language	English (US)
Pages (from-to)	S151-S155
Journal	Annals of neurology
Volume	23
Issue number	1 S
DOIs	https://doi.org/10.1002/ana.410230734
State	Published - 1988

ASJC Scopus subject areas

Neurology
Clinical Neurology

Access to Document

10.1002/ana.410230734

Cite this

@article{97d87075d9cd49ea8d37942aebd18292,

title = "Spastic paraparesis and HTLV‐I infection in peru",

abstract = "Three of 6 patients with spastic paraparesis in Lima, Peru, were found to have antibodies to human T‐lymphotropic virus type I (HTLV‐I). Blood and cerebrospinal fluid antibodies were confirmed by Western blot analysis. Multilobulated lymphocytes in blood and cerebrospinal fluid of the index case stained with monoclonal antibodies for T‐helper cells and for T10, an activation marker. Blood mononuclear cells from patients with HTLV‐I–associated myelopathy showed spontaneous proliferation in culture, evidence of interleukin‐2 receptors, and decreased natural killer cell activity.",

author = "Johnson, {Richard T.} and Griffin, {Diane E.} and Alberto Arregui and Carlos Mora and Gibbs, {Clarence J.} and Cuba, {Juan M.} and Luis Trelles and Abraham Vaisberg",

year = "1988",

doi = "10.1002/ana.410230734",

language = "English (US)",

volume = "23",

pages = "S151--S155",

journal = "Annals of neurology",

issn = "0364-5134",

publisher = "John Wiley & Sons Inc.",

number = "1 S",

}

TY - JOUR

T1 - Spastic paraparesis and HTLV‐I infection in peru

AU - Johnson, Richard T.

AU - Griffin, Diane E.

AU - Arregui, Alberto

AU - Mora, Carlos

AU - Gibbs, Clarence J.

AU - Cuba, Juan M.

AU - Trelles, Luis

AU - Vaisberg, Abraham

PY - 1988

Y1 - 1988

N2 - Three of 6 patients with spastic paraparesis in Lima, Peru, were found to have antibodies to human T‐lymphotropic virus type I (HTLV‐I). Blood and cerebrospinal fluid antibodies were confirmed by Western blot analysis. Multilobulated lymphocytes in blood and cerebrospinal fluid of the index case stained with monoclonal antibodies for T‐helper cells and for T10, an activation marker. Blood mononuclear cells from patients with HTLV‐I–associated myelopathy showed spontaneous proliferation in culture, evidence of interleukin‐2 receptors, and decreased natural killer cell activity.

AB - Three of 6 patients with spastic paraparesis in Lima, Peru, were found to have antibodies to human T‐lymphotropic virus type I (HTLV‐I). Blood and cerebrospinal fluid antibodies were confirmed by Western blot analysis. Multilobulated lymphocytes in blood and cerebrospinal fluid of the index case stained with monoclonal antibodies for T‐helper cells and for T10, an activation marker. Blood mononuclear cells from patients with HTLV‐I–associated myelopathy showed spontaneous proliferation in culture, evidence of interleukin‐2 receptors, and decreased natural killer cell activity.

UR - http://www.scopus.com/inward/record.url?scp=0023784512&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023784512&partnerID=8YFLogxK

U2 - 10.1002/ana.410230734

DO - 10.1002/ana.410230734

M3 - Article

C2 - 2894807

AN - SCOPUS:0023784512

SN - 0364-5134

VL - 23

SP - S151-S155

JO - Annals of neurology

JF - Annals of neurology

IS - 1 S

ER -

Spastic paraparesis and HTLV‐I infection in peru

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this