SPAK isoforms and OSR1 regulate sodium-chloride co-transporters in a nephron-specific manner

P. Richard Grimm; Tarvinder K. Taneja; Jie Liu; Richard Coleman; Yang Yi Chen; Eric Delpire; James B. Wade; Paul A. Welling

doi:10.1074/jbc.M112.402800

SPAK isoforms and OSR1 regulate sodium-chloride co-transporters in a nephron-specific manner

P. Richard Grimm, Tarvinder K. Taneja, Jie Liu, Richard Coleman, Yang Yi Chen, Eric Delpire, James B. Wade, Paul A. Welling

Research output: Contribution to journal › Article › peer-review

81 Scopus citations

Abstract

Background: Full-length SPAK is thought to be necessary and sufficient to activate NCC in the distal convoluted tubule (DCT). Results: SPAK knock-out disrupts a signaling network, involving OSR1, in the DCT but not the TAL, preventing NCC activation. Conclusion: SPAK and OSR1 function interdependently in the DCT to positively regulate NCC. Significance: This study provides insights into the mechanisms whereby SPAK/OSR1 regulates renal salt transport.

Original language	English (US)
Pages (from-to)	37673-37690
Number of pages	18
Journal	Journal of Biological Chemistry
Volume	287
Issue number	45
DOIs	https://doi.org/10.1074/jbc.M112.402800
State	Published - Nov 2 2012
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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title = "SPAK isoforms and OSR1 regulate sodium-chloride co-transporters in a nephron-specific manner",

abstract = "Background: Full-length SPAK is thought to be necessary and sufficient to activate NCC in the distal convoluted tubule (DCT). Results: SPAK knock-out disrupts a signaling network, involving OSR1, in the DCT but not the TAL, preventing NCC activation. Conclusion: SPAK and OSR1 function interdependently in the DCT to positively regulate NCC. Significance: This study provides insights into the mechanisms whereby SPAK/OSR1 regulates renal salt transport.",

author = "Grimm, {P. Richard} and Taneja, {Tarvinder K.} and Jie Liu and Richard Coleman and Chen, {Yang Yi} and Eric Delpire and Wade, {James B.} and Welling, {Paul A.}",

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doi = "10.1074/jbc.M112.402800",

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T1 - SPAK isoforms and OSR1 regulate sodium-chloride co-transporters in a nephron-specific manner

AU - Grimm, P. Richard

AU - Taneja, Tarvinder K.

AU - Liu, Jie

AU - Coleman, Richard

AU - Chen, Yang Yi

AU - Delpire, Eric

AU - Wade, James B.

AU - Welling, Paul A.

PY - 2012/11/2

Y1 - 2012/11/2

N2 - Background: Full-length SPAK is thought to be necessary and sufficient to activate NCC in the distal convoluted tubule (DCT). Results: SPAK knock-out disrupts a signaling network, involving OSR1, in the DCT but not the TAL, preventing NCC activation. Conclusion: SPAK and OSR1 function interdependently in the DCT to positively regulate NCC. Significance: This study provides insights into the mechanisms whereby SPAK/OSR1 regulates renal salt transport.

AB - Background: Full-length SPAK is thought to be necessary and sufficient to activate NCC in the distal convoluted tubule (DCT). Results: SPAK knock-out disrupts a signaling network, involving OSR1, in the DCT but not the TAL, preventing NCC activation. Conclusion: SPAK and OSR1 function interdependently in the DCT to positively regulate NCC. Significance: This study provides insights into the mechanisms whereby SPAK/OSR1 regulates renal salt transport.

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SPAK isoforms and OSR1 regulate sodium-chloride co-transporters in a nephron-specific manner

Abstract

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