TY - JOUR
T1 - Soy Milk Consumption and Blood Pressure Among Type 2 Diabetic Patients With Nephropathy
AU - Miraghajani, Maryam Sadat
AU - Najafabadi, Mojgan Mortazavi
AU - Surkan, Pamela J.
AU - Esmaillzadeh, Ahmad
AU - Mirlohi, Maryam
AU - Azadbakht, Leila
N1 - Funding Information:
This study was supported by the Isfahan University of Medical Sciences , Isfahan, Iran. No potential conflicts of interest relevant to this article were reported. M.S.M., A.E., M.M.N., M.M., and L.A. conceptualized and designed the study and drafted the manuscript. M.S.M. and L.A. analyzed and interpreted data. P.J.S. edited the paper, provided comments, and corrected the English. The authors thank Dr. Gabriel Brandt from Johns Hopkins Bloomberg School of Public Health, who carefully read and commented on the manuscript. Dr. Leila Azadbakht is the guarantor of this work and, as such, had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
PY - 2013/7
Y1 - 2013/7
N2 - Objective: The purpose of this study was to determine the effects of soy milk consumption cardiovascular risk and biomarkers of renal function in type 2 diabetic patients with nephropathy. Methods: This randomized, crossover, controlled clinical trial was conducted in 29 type 2 diabetic patients with nephropathy. Participants were randomly assigned to consume a diet containing soy milk, or a diet containing cow's milk, each for 4 weeks. There was a 2-week washout between the two intervention periods. Anthropometric and biochemical measurements were performed according to standard protocols. Results: The mean age and body mass index of patients were 51 ± 10 years and 28 ± 4 kg/m2, respectively. Consumption of soy milk resulted in a significant reduction in systolic blood pressure compared with consumption of cow's milk (percent change: -4.50 vs. 5.89%; P=03). Serum triglyceride levels decreased significantly after soy milk consumption (percent change: -15.22 vs. 2.37%; P=02). After adjustment for carbohydrate intake, the effect of soy milk on triglyceride level was not significant. There were no significant differences between soy milk and cow's milk consumption in terms of their effect on cardiovascular risks and markers of kidney function. Conclusions: Soy milk consumption was associated with better blood pressure control among diabetic patients with nephropathy.
AB - Objective: The purpose of this study was to determine the effects of soy milk consumption cardiovascular risk and biomarkers of renal function in type 2 diabetic patients with nephropathy. Methods: This randomized, crossover, controlled clinical trial was conducted in 29 type 2 diabetic patients with nephropathy. Participants were randomly assigned to consume a diet containing soy milk, or a diet containing cow's milk, each for 4 weeks. There was a 2-week washout between the two intervention periods. Anthropometric and biochemical measurements were performed according to standard protocols. Results: The mean age and body mass index of patients were 51 ± 10 years and 28 ± 4 kg/m2, respectively. Consumption of soy milk resulted in a significant reduction in systolic blood pressure compared with consumption of cow's milk (percent change: -4.50 vs. 5.89%; P=03). Serum triglyceride levels decreased significantly after soy milk consumption (percent change: -15.22 vs. 2.37%; P=02). After adjustment for carbohydrate intake, the effect of soy milk on triglyceride level was not significant. There were no significant differences between soy milk and cow's milk consumption in terms of their effect on cardiovascular risks and markers of kidney function. Conclusions: Soy milk consumption was associated with better blood pressure control among diabetic patients with nephropathy.
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U2 - 10.1053/j.jrn.2013.01.017
DO - 10.1053/j.jrn.2013.01.017
M3 - Article
C2 - 23498346
AN - SCOPUS:84879420652
SN - 1051-2276
VL - 23
SP - 277-282.e1
JO - Journal of Renal Nutrition
JF - Journal of Renal Nutrition
IS - 4
ER -