SOS mutagenesis

Sumati Murli; Graham C. Walker

doi:10.1016/S0959-437X(05)80089-9

SOS mutagenesis

Sumati Murli
, Graham C. Walker

Research output: Contribution to journal › Article › peer-review

Abstract

In Esherichia coli, UV and many chemical appear to cause mutagenesis by a process of translesion synthesis that requires some form of DNA polymerase III and the SOS-regulated proteins UmuD, UmuC and RecA. An analysis of SOS mutagenesis offers insights into the molecular basis of induced mutagenesis and into mechanisms of DNA damage tolerance.

Original language	English (US)
Pages (from-to)	719-725
Number of pages	7
Journal	Current Opinion in Genetics and Development
Volume	3
Issue number	5
DOIs	https://doi.org/10.1016/S0959-437X(05)80089-9
State	Published - Oct 1993
Externally published	Yes

ASJC Scopus subject areas

Genetics
Developmental Biology

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10.1016/S0959-437X(05)80089-9

Cite this

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title = "SOS mutagenesis",

abstract = "In Esherichia coli, UV and many chemical appear to cause mutagenesis by a process of translesion synthesis that requires some form of DNA polymerase III and the SOS-regulated proteins UmuD, UmuC and RecA. An analysis of SOS mutagenesis offers insights into the molecular basis of induced mutagenesis and into mechanisms of DNA damage tolerance.",

author = "Sumati Murli and Walker, \{Graham C.\}",

note = "Funding Information: This work was supported by Public Health Service grant CA2.1615 awarded by the National Cancer Institute. S.M. w',t,; supported by Pred(x:toral Training Grant 5T32GM07287 from the Natkmal Institutes of Health.",

year = "1993",

month = oct,

doi = "10.1016/S0959-437X(05)80089-9",

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AU - Walker, Graham C.

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PY - 1993/10

Y1 - 1993/10

N2 - In Esherichia coli, UV and many chemical appear to cause mutagenesis by a process of translesion synthesis that requires some form of DNA polymerase III and the SOS-regulated proteins UmuD, UmuC and RecA. An analysis of SOS mutagenesis offers insights into the molecular basis of induced mutagenesis and into mechanisms of DNA damage tolerance.

AB - In Esherichia coli, UV and many chemical appear to cause mutagenesis by a process of translesion synthesis that requires some form of DNA polymerase III and the SOS-regulated proteins UmuD, UmuC and RecA. An analysis of SOS mutagenesis offers insights into the molecular basis of induced mutagenesis and into mechanisms of DNA damage tolerance.

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U2 - 10.1016/S0959-437X(05)80089-9

DO - 10.1016/S0959-437X(05)80089-9

M3 - Article

C2 - 8274853

AN - SCOPUS:0027420738

SN - 0959-437X

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JO - Current Opinion in Genetics and Development

JF - Current Opinion in Genetics and Development

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ER -

SOS mutagenesis

Abstract

ASJC Scopus subject areas

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