Some neurotransmitter relationships in the carotid body’s response to hypoxia

Robert S. Fitzgerald, Serabi Hirasawa, Machiko Shirahata, Hay Yan Wang

Research output: Chapter in Book/Report/Conference proceedingChapter


The carotid body is the primary sensor of hypoxemia across many species. When stimulated by a decrease in PaO2, or hypoxic perfusates, it promotes many cardiopulmonary responses. Ventilation, static lung volumes, airway resistance, and airway secretions increase. The hypoxic pulmonary vasoconstrictor response and the systemic vascular vasodilator responses are attenuated; bronchial vascular resistance decreases (for review see Ref. 1). A current question is: How does the carotid body transduce a low PaO2, stimulus into increased neural output traveling to the nucleus tracrus solitarii? Here the increased neural traffic is processed and distributed to various other nuclei responsible for the increased breathing and the autonomically regulated changes in the cardiopulmonary system.

Original languageEnglish (US)
Title of host publicationOxygen Sensing
Subtitle of host publicationResponses and Adaption to Hypoxia
PublisherCRC Press
Number of pages16
ISBN (Electronic)9780824748456
ISBN (Print)9780824709600
StatePublished - Jan 1 2003

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'Some neurotransmitter relationships in the carotid body’s response to hypoxia'. Together they form a unique fingerprint.

Cite this