Somatostatinergic neurites in senile plaques of aged non-human primates

Robert G. Struble; Cheryl A. Kitt; Lary C. Walker; Linda C. Cork; Donald L. Price

doi:10.1016/0006-8993(84)90057-X

Somatostatinergic neurites in senile plaques of aged non-human primates

Robert G. Struble, Cheryl A. Kitt, Lary C. Walker, Linda C. Cork, Donald L. Price

School of Medicine

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

Using a polyclonal antibody directed against somatostatin, normal somatostatin-positive neurons and fibers were seen in the amygdala and periamygdaloid cortex of both young and aged macaques. In addition, immunoreactive structures, identical in appearance to neurites demonstrated by silver impregnation methods, were seen in the amygdala of one aged monkey that exhibited numerous senile plaques. Some of these immunoreactive neurites were associated with deposits of amyloid, as seen with thioflavin-T stains, suggesting that these were neurites of senile plaques. This study provides direct evidence for abnormalities in peptidergic neurons in brains of aged non-human primates.

Original language	English (US)
Pages (from-to)	394-396
Number of pages	3
Journal	Brain research
Volume	324
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(84)90057-X
State	Published - Dec 24 1984

Keywords

Alzheimer's disease
aged brain
senile plaques
somatostatin

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(84)90057-X

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title = "Somatostatinergic neurites in senile plaques of aged non-human primates",

abstract = "Using a polyclonal antibody directed against somatostatin, normal somatostatin-positive neurons and fibers were seen in the amygdala and periamygdaloid cortex of both young and aged macaques. In addition, immunoreactive structures, identical in appearance to neurites demonstrated by silver impregnation methods, were seen in the amygdala of one aged monkey that exhibited numerous senile plaques. Some of these immunoreactive neurites were associated with deposits of amyloid, as seen with thioflavin-T stains, suggesting that these were neurites of senile plaques. This study provides direct evidence for abnormalities in peptidergic neurons in brains of aged non-human primates.",

keywords = "Alzheimer's disease, aged brain, senile plaques, somatostatin",

author = "Struble, {Robert G.} and Kitt, {Cheryl A.} and Walker, {Lary C.} and Cork, {Linda C.} and Price, {Donald L.}",

note = "Funding Information: The authors thank the ('arribean Primate Center of the University of Puerto Rico School of Medicine for making these aged animals ~vailable fi)r study. The authors gratefully acknowledge helpful discussions with Drs. William C. Mobley, Manuel F. Casanova, Peter J. Whitehouse ~t~)d George R. Uhl. Mr. Mark Becher, Mr. Richard Altschuler and Ms. Barbara Holden provided excellent technical help, and Mrs. Carla Jordon and Ms. Nancy Cook assisted in the manuscript preparation. 7'his work was supported by grants from the U.S. Public Health Service (NIH AG 03359, NS 20471, NS 15721, NS |0580, NS 07179 and RR 05378) and a gram from The Johns Hopkins University School of Medicine. L.C.C. is the recipient of a Research Career Development Award (NIH NS 00488).",

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doi = "10.1016/0006-8993(84)90057-X",

language = "English (US)",

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AU - Struble, Robert G.

AU - Kitt, Cheryl A.

AU - Walker, Lary C.

AU - Cork, Linda C.

AU - Price, Donald L.

N1 - Funding Information: The authors thank the ('arribean Primate Center of the University of Puerto Rico School of Medicine for making these aged animals ~vailable fi)r study. The authors gratefully acknowledge helpful discussions with Drs. William C. Mobley, Manuel F. Casanova, Peter J. Whitehouse ~t~)d George R. Uhl. Mr. Mark Becher, Mr. Richard Altschuler and Ms. Barbara Holden provided excellent technical help, and Mrs. Carla Jordon and Ms. Nancy Cook assisted in the manuscript preparation. 7'his work was supported by grants from the U.S. Public Health Service (NIH AG 03359, NS 20471, NS 15721, NS |0580, NS 07179 and RR 05378) and a gram from The Johns Hopkins University School of Medicine. L.C.C. is the recipient of a Research Career Development Award (NIH NS 00488).

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Y1 - 1984/12/24

N2 - Using a polyclonal antibody directed against somatostatin, normal somatostatin-positive neurons and fibers were seen in the amygdala and periamygdaloid cortex of both young and aged macaques. In addition, immunoreactive structures, identical in appearance to neurites demonstrated by silver impregnation methods, were seen in the amygdala of one aged monkey that exhibited numerous senile plaques. Some of these immunoreactive neurites were associated with deposits of amyloid, as seen with thioflavin-T stains, suggesting that these were neurites of senile plaques. This study provides direct evidence for abnormalities in peptidergic neurons in brains of aged non-human primates.

AB - Using a polyclonal antibody directed against somatostatin, normal somatostatin-positive neurons and fibers were seen in the amygdala and periamygdaloid cortex of both young and aged macaques. In addition, immunoreactive structures, identical in appearance to neurites demonstrated by silver impregnation methods, were seen in the amygdala of one aged monkey that exhibited numerous senile plaques. Some of these immunoreactive neurites were associated with deposits of amyloid, as seen with thioflavin-T stains, suggesting that these were neurites of senile plaques. This study provides direct evidence for abnormalities in peptidergic neurons in brains of aged non-human primates.

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KW - senile plaques

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Somatostatinergic neurites in senile plaques of aged non-human primates

Abstract

Keywords

ASJC Scopus subject areas

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