Somatostatin in human pancreatic and gastric juice

A. Arimura; K. Groot; T. Taminato; A. Ertan; K. Akdamar; J. Ryan; K. Pienta; A. I. Vinik

doi:10.1016/0196-9781(81)90044-9

Somatostatin in human pancreatic and gastric juice

A. Arimura, K. Groot, T. Taminato, A. Ertan, K. Akdamar, J. Ryan, K. Pienta, A. I. Vinik

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Considerable amounts of IRS are secreted after secretin injection in human pancreatic juice collected during endoscopic retrograde cholangiopancreatography. The mean IRS levels in the pancreatic juice of non-diabetic patients were 79±10 (SE) pg/ml. The IRS levels in NIDDM were considerably higher, the mean value being 1635±313 (SE) pg/ml. The mean IRS level in IDDM were 312±151 (SE) pg/ml. In IDDM, those patients whose blood glucose levels were well controlled by insulin showed low pancreatic juice IRS ranging from non-detectable to 46 pg/ml. On the other hand, those with uncontrolled hyperglycemia showed IRS levels ranging from 452 to 1047 pg/ml. Gel-filtration profiles of IRS in pancreatic juice extracts were not consistent in all cases. Some showed IRS peaks eluting with SS14 and SS28, while others contained IRS species that were eluted in more retarded fractions. The retarded IRS fraction exhibited biological activity indistinguishable from that of SS14 as indexed using a quantitative cytochemical method.

Original language	English (US)
Pages (from-to)	271-274
Number of pages	4
Journal	Peptides
Volume	2
Issue number	SUPPL. 2
DOIs	https://doi.org/10.1016/0196-9781(81)90044-9
State	Published - 1981
Externally published	Yes

Keywords

Endoscopic retrograde cholangiopancreatography (ERCP)
Gastric juice
Insulin dependent diabetes mellitus (IDDM)
Non-insulin dependent diabetes mellitus (NIDDM)
Oxyntic cells
Pancreatic juice
Pentagastrin
Secretin
Somatostatin (SS14)
Somatostatin 28 (SS28)

ASJC Scopus subject areas

Biochemistry
Physiology
Endocrinology
Cellular and Molecular Neuroscience

Access to Document

10.1016/0196-9781(81)90044-9

Cite this

@article{5a2aafbd3eea456e9a32ad94e3067925,

title = "Somatostatin in human pancreatic and gastric juice",

abstract = "Considerable amounts of IRS are secreted after secretin injection in human pancreatic juice collected during endoscopic retrograde cholangiopancreatography. The mean IRS levels in the pancreatic juice of non-diabetic patients were 79±10 (SE) pg/ml. The IRS levels in NIDDM were considerably higher, the mean value being 1635±313 (SE) pg/ml. The mean IRS level in IDDM were 312±151 (SE) pg/ml. In IDDM, those patients whose blood glucose levels were well controlled by insulin showed low pancreatic juice IRS ranging from non-detectable to 46 pg/ml. On the other hand, those with uncontrolled hyperglycemia showed IRS levels ranging from 452 to 1047 pg/ml. Gel-filtration profiles of IRS in pancreatic juice extracts were not consistent in all cases. Some showed IRS peaks eluting with SS14 and SS28, while others contained IRS species that were eluted in more retarded fractions. The retarded IRS fraction exhibited biological activity indistinguishable from that of SS14 as indexed using a quantitative cytochemical method.",

keywords = "Endoscopic retrograde cholangiopancreatography (ERCP), Gastric juice, Insulin dependent diabetes mellitus (IDDM), Non-insulin dependent diabetes mellitus (NIDDM), Oxyntic cells, Pancreatic juice, Pentagastrin, Secretin, Somatostatin (SS14), Somatostatin 28 (SS28)",

author = "A. Arimura and K. Groot and T. Taminato and A. Ertan and K. Akdamar and J. Ryan and K. Pienta and Vinik, {A. I.}",

year = "1981",

doi = "10.1016/0196-9781(81)90044-9",

language = "English (US)",

volume = "2",

pages = "271--274",

journal = "Peptides",

issn = "0196-9781",

publisher = "Elsevier Inc.",

number = "SUPPL. 2",

}

TY - JOUR

T1 - Somatostatin in human pancreatic and gastric juice

AU - Arimura, A.

AU - Groot, K.

AU - Taminato, T.

AU - Ertan, A.

AU - Akdamar, K.

AU - Ryan, J.

AU - Pienta, K.

AU - Vinik, A. I.

PY - 1981

Y1 - 1981

N2 - Considerable amounts of IRS are secreted after secretin injection in human pancreatic juice collected during endoscopic retrograde cholangiopancreatography. The mean IRS levels in the pancreatic juice of non-diabetic patients were 79±10 (SE) pg/ml. The IRS levels in NIDDM were considerably higher, the mean value being 1635±313 (SE) pg/ml. The mean IRS level in IDDM were 312±151 (SE) pg/ml. In IDDM, those patients whose blood glucose levels were well controlled by insulin showed low pancreatic juice IRS ranging from non-detectable to 46 pg/ml. On the other hand, those with uncontrolled hyperglycemia showed IRS levels ranging from 452 to 1047 pg/ml. Gel-filtration profiles of IRS in pancreatic juice extracts were not consistent in all cases. Some showed IRS peaks eluting with SS14 and SS28, while others contained IRS species that were eluted in more retarded fractions. The retarded IRS fraction exhibited biological activity indistinguishable from that of SS14 as indexed using a quantitative cytochemical method.

AB - Considerable amounts of IRS are secreted after secretin injection in human pancreatic juice collected during endoscopic retrograde cholangiopancreatography. The mean IRS levels in the pancreatic juice of non-diabetic patients were 79±10 (SE) pg/ml. The IRS levels in NIDDM were considerably higher, the mean value being 1635±313 (SE) pg/ml. The mean IRS level in IDDM were 312±151 (SE) pg/ml. In IDDM, those patients whose blood glucose levels were well controlled by insulin showed low pancreatic juice IRS ranging from non-detectable to 46 pg/ml. On the other hand, those with uncontrolled hyperglycemia showed IRS levels ranging from 452 to 1047 pg/ml. Gel-filtration profiles of IRS in pancreatic juice extracts were not consistent in all cases. Some showed IRS peaks eluting with SS14 and SS28, while others contained IRS species that were eluted in more retarded fractions. The retarded IRS fraction exhibited biological activity indistinguishable from that of SS14 as indexed using a quantitative cytochemical method.

KW - Endoscopic retrograde cholangiopancreatography (ERCP)

KW - Gastric juice

KW - Insulin dependent diabetes mellitus (IDDM)

KW - Non-insulin dependent diabetes mellitus (NIDDM)

KW - Oxyntic cells

KW - Pancreatic juice

KW - Pentagastrin

KW - Secretin

KW - Somatostatin (SS14)

KW - Somatostatin 28 (SS28)

UR - http://www.scopus.com/inward/record.url?scp=0019852317&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019852317&partnerID=8YFLogxK

U2 - 10.1016/0196-9781(81)90044-9

DO - 10.1016/0196-9781(81)90044-9

M3 - Article

C2 - 6123989

AN - SCOPUS:0019852317

SN - 0196-9781

VL - 2

SP - 271

EP - 274

JO - Peptides

JF - Peptides

IS - SUPPL. 2

ER -

Somatostatin in human pancreatic and gastric juice

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this