TY - JOUR
T1 - Somatosensory Stimulation Enhances the Effects of Training Functional Hand Tasks in Patients With Chronic Stroke
AU - Celnik, Pablo
AU - Hummel, Friedhelm
AU - Harris-Love, Michelle
AU - Wolk, Rebecca
AU - Cohen, Leonardo G.
PY - 2007/11
Y1 - 2007/11
N2 - Celnik P, Hummel F, Harris-Love M, Wolk R, Cohen LG. Somatosensory stimulation enhances the effects of training functional hand tasks in patients with chronic stroke. Objective: To test the hypothesis that somatosensory stimulation would enhance the effects of training functional hand tasks immediately after practice and 1 day later in chronic subcortical stroke patients. Design: Single-blinded and randomized, crossover study. Setting: Human research laboratory. Participants: Nine chronic subcortical stroke patients. Interventions: Three separate sessions of motor training preceded by (1) synchronous peripheral nerve stimulation (PNS), (2) no stimulation, or (3) asynchronous PNS. Main Outcome Measures: Time to complete the Jebsen-Taylor Hand Function Test (JTHFT time) and corticomotor excitability tested with transcranial magnetic stimulation. Results: After familiarization practice, during which all patients reached a performance plateau, training under the effects of PNS reduced JTHFT time by 10% beyond the post-familiarization plateau. This behavioral gain was accompanied by a specific reduction in GABAergically mediated intracortical inhibition in the motor cortex. These findings were not observed after similar practice under the influence of no stimulation or asynchronous PNS sessions. Conclusions: Somatosensory stimulation may enhance the training of functional hand tasks in patients with chronic stroke, possibly through modulation of intracortical GABAergic pathways.
AB - Celnik P, Hummel F, Harris-Love M, Wolk R, Cohen LG. Somatosensory stimulation enhances the effects of training functional hand tasks in patients with chronic stroke. Objective: To test the hypothesis that somatosensory stimulation would enhance the effects of training functional hand tasks immediately after practice and 1 day later in chronic subcortical stroke patients. Design: Single-blinded and randomized, crossover study. Setting: Human research laboratory. Participants: Nine chronic subcortical stroke patients. Interventions: Three separate sessions of motor training preceded by (1) synchronous peripheral nerve stimulation (PNS), (2) no stimulation, or (3) asynchronous PNS. Main Outcome Measures: Time to complete the Jebsen-Taylor Hand Function Test (JTHFT time) and corticomotor excitability tested with transcranial magnetic stimulation. Results: After familiarization practice, during which all patients reached a performance plateau, training under the effects of PNS reduced JTHFT time by 10% beyond the post-familiarization plateau. This behavioral gain was accompanied by a specific reduction in GABAergically mediated intracortical inhibition in the motor cortex. These findings were not observed after similar practice under the influence of no stimulation or asynchronous PNS sessions. Conclusions: Somatosensory stimulation may enhance the training of functional hand tasks in patients with chronic stroke, possibly through modulation of intracortical GABAergic pathways.
KW - Electric stimulation
KW - Motor skills
KW - Rehabilitation
KW - Stroke
UR - http://www.scopus.com/inward/record.url?scp=35448998063&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=35448998063&partnerID=8YFLogxK
U2 - 10.1016/j.apmr.2007.08.001
DO - 10.1016/j.apmr.2007.08.001
M3 - Article
C2 - 17964875
AN - SCOPUS:35448998063
SN - 0003-9993
VL - 88
SP - 1369
EP - 1376
JO - Archives of physical medicine and rehabilitation
JF - Archives of physical medicine and rehabilitation
IS - 11
ER -