Soluble benzodiazepine receptors: Gabaergic regulation

Moshe Gavish; Solomon H. Snyder

doi:10.1016/0024-3205(80)90231-3

Soluble benzodiazepine receptors: Gabaergic regulation

Moshe Gavish, Solomon H. Snyder

School of Medicine

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

Benzodiazepine receptor binding has been measured in soluble brain extracts with ³H-flunitrazepam as a ligand. Binding to soluble receptors is enhanced by GABAergic agonists with potencies and maximal augmentation essentially the same as on membrane bound benzodiazepine receptors. The GABA induced increase of binding to soluble receptors is reversed by the GABA antagonist bicuculline.

Original language	English (US)
Pages (from-to)	579-582
Number of pages	4
Journal	Life Sciences
Volume	26
Issue number	8
DOIs	https://doi.org/10.1016/0024-3205(80)90231-3
State	Published - Feb 25 1980

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/0024-3205(80)90231-3

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title = "Soluble benzodiazepine receptors: Gabaergic regulation",

abstract = "Benzodiazepine receptor binding has been measured in soluble brain extracts with 3H-flunitrazepam as a ligand. Binding to soluble receptors is enhanced by GABAergic agonists with potencies and maximal augmentation essentially the same as on membrane bound benzodiazepine receptors. The GABA induced increase of binding to soluble receptors is reversed by the GABA antagonist bicuculline.",

author = "Moshe Gavish and Snyder, {Solomon H.}",

note = "Funding Information: Supported by USPHS grants MH.18501, DA.00266 and grants of the Hartford and McKnight foundations. Moshe Garish supported by Damon Runyon fellowship. We wish to thank Dawn Hanks for manuscript preparation and Creg Mack for technical assistance.",

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AU - Gavish, Moshe

AU - Snyder, Solomon H.

N1 - Funding Information: Supported by USPHS grants MH.18501, DA.00266 and grants of the Hartford and McKnight foundations. Moshe Garish supported by Damon Runyon fellowship. We wish to thank Dawn Hanks for manuscript preparation and Creg Mack for technical assistance.

PY - 1980/2/25

Y1 - 1980/2/25

N2 - Benzodiazepine receptor binding has been measured in soluble brain extracts with 3H-flunitrazepam as a ligand. Binding to soluble receptors is enhanced by GABAergic agonists with potencies and maximal augmentation essentially the same as on membrane bound benzodiazepine receptors. The GABA induced increase of binding to soluble receptors is reversed by the GABA antagonist bicuculline.

AB - Benzodiazepine receptor binding has been measured in soluble brain extracts with 3H-flunitrazepam as a ligand. Binding to soluble receptors is enhanced by GABAergic agonists with potencies and maximal augmentation essentially the same as on membrane bound benzodiazepine receptors. The GABA induced increase of binding to soluble receptors is reversed by the GABA antagonist bicuculline.

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ER -

Soluble benzodiazepine receptors: Gabaergic regulation

Abstract

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