Software for constructing and verifying pedigrees within large genealogies and an application to the Old Older Amish of Lancaster County

Richa Agarwala; Leslie G. Biesecker; Katherine A. Hopkins; Clair A. Francomano; Alejandro A. Schaffer

doi:10.1101/gr.8.3.211

Software for constructing and verifying pedigrees within large genealogies and an application to the Old Older Amish of Lancaster County

Richa Agarwala, Leslie G. Biesecker, Katherine A. Hopkins, Clair A. Francomano, Alejandro A. Schaffer

School of Medicine

Research output: Contribution to journal › Article › peer-review

90 Scopus citations

Abstract

This paper describes PedHunter, a software package that facilitates creation and verification of pedigrees within large genealogies. A frequent problem in medical genetics is to connect distant relatives with a pedigree. PedHunter uses methods from graph theory to solve two versions of the pedigree connection problem for genealogies as well as other pedigree analysis problems. The pedigrees are produced by PedHunter as files in LINKAGE format ready for linkage analysis. PedHunter uses a relational database of genealogy data, with tables in specified format, for all calculations. The functionality and utility of PedHunter are illustrated by examples using the Amish Genealogy Database (AGDB), which was created for the Old Order Amish community of Lancaster County, Pennsylvania.

Original language	English (US)
Pages (from-to)	211-221
Number of pages	11
Journal	Genome research
Volume	8
Issue number	3
DOIs	https://doi.org/10.1101/gr.8.3.211
State	Published - Mar 1998

ASJC Scopus subject areas

Genetics
Genetics(clinical)

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10.1101/gr.8.3.211

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abstract = "This paper describes PedHunter, a software package that facilitates creation and verification of pedigrees within large genealogies. A frequent problem in medical genetics is to connect distant relatives with a pedigree. PedHunter uses methods from graph theory to solve two versions of the pedigree connection problem for genealogies as well as other pedigree analysis problems. The pedigrees are produced by PedHunter as files in LINKAGE format ready for linkage analysis. PedHunter uses a relational database of genealogy data, with tables in specified format, for all calculations. The functionality and utility of PedHunter are illustrated by examples using the Amish Genealogy Database (AGDB), which was created for the Old Order Amish community of Lancaster County, Pennsylvania.",

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AU - Schaffer, Alejandro A.

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Software for constructing and verifying pedigrees within large genealogies and an application to the Old Older Amish of Lancaster County

Abstract

ASJC Scopus subject areas

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