Modello socio-economico della vaccinazione anti-rotavirus nella regione di Castilla y León, Spagna

Translated title of the contribution: Socio-economic modeling of rotavirus vaccination in Castilla y León, Spain

Alberto Pérez-Rubio, Francisco Javier Luquero, Jose María Eiros Bouza, Jose Javier Castrodeza Sanz, Maria del Rosario Bachiller Luque, Raúl Ortiz de Lejarazu, Antonio Sánchez Port

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Rotavirus is one of the main causes of acute gastroenteritis in infants and young children. Furthermore, rotavirus is the leading cause of hospitalization and death from acute gastroenteritis among infants and young children worldwide. Although death due to rotavirus is rare in industrialized regions such as Spain, the rotavirus disease burden and its economic impact is severe. This study aims to assess systematic vaccination against rotavirus economically and socially in a Spanish region. Economic cost-effectiveness and cost-benefit assessment through a choice tree was designed. We estimated health provider costs, economic costs and quality-adjusted life years (QALYs) lost due to rotavirus infections. The study includes a fictitious cohort of 100,000 children from Castilla y León who were also administered the rotavirus vaccine together with diphtheria and tetanus toxoids and pertussis (DTP). The study adopted a society and health care system perspective. A sensitivity analysis was developed to assess the uncertainty of some variables. According to the estimated incidence rate for children in Castilla y León, rotavirus immunization is projected to prevent 45% of cases with RotaTeq® and 57% with Rotarix®. The respective cost per QALY is about € 75,000 and 50,000 from the perspective of the health care system. Routine infant vaccination in Castilla y León using either rotavirus vaccine is not profitable from the payer's perspective and is not cost-effective under basic case assumptions unless the vaccine is available at a lower cost.

Translated title of the contributionSocio-economic modeling of rotavirus vaccination in Castilla y León, Spain
Original languageItalian
Pages (from-to)166-175
Number of pages10
JournalInfezioni in Medicina
Issue number3
StatePublished - Sep 2011
Externally publishedYes


  • Cost-benefit
  • Costeffectiveness
  • Rotavirus infection
  • Vaccination

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases


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