Smooth pursuit eye movements in schizophrenia: Effects of neuroleptic treatment and caffeine

R. E. Litman; D. W. Hommer; T. Clem; M. H. Rapaport; C. N. Pato; D. Pickar

Smooth pursuit eye movements in schizophrenia: Effects of neuroleptic treatment and caffeine

R. E. Litman, D. W. Hommer, T. Clem, M. H. Rapaport, C. N. Pato, D. Pickar

Research output: Contribution to journal › Article › peer-review

Abstract

Abnormal smooth pursuit eye movement (SPEM) has been proposed as a trait marker in schizophrenia. We utilized high resolution infra-red oculography to measure SPEM in 11 neuroleptic-treated schizophrenic patients, 10 drug-free schizophrenic patients, and 11 normals. The most characteristic abnormality was a significant increase in saccadic intrusions during SPEM in schizophrenic patients (p <.001). SPEM gain was reduced in schizophrenic patients (p <.005). No significant effects of neuroleptic treatment on SPEM were found, including analysis of seven patients in whom paired data was available. We also measured SPEM prior to and after caffeine ingestion (10 mg/kg) in 10 normals. We found reduced saccadic interruptions as a result of caffeine ingestion compared with placebo (p

Original language	English (US)
Pages (from-to)	473-478
Number of pages	6
Journal	Psychopharmacology Bulletin
Volume	25
Issue number	3
State	Published - 1989
Externally published	Yes

ASJC Scopus subject areas

Psychiatry and Mental health
Pharmacology

Cite this

@article{61958780fc664720a9c4d69517acb93a,

title = "Smooth pursuit eye movements in schizophrenia: Effects of neuroleptic treatment and caffeine",

abstract = "Abnormal smooth pursuit eye movement (SPEM) has been proposed as a trait marker in schizophrenia. We utilized high resolution infra-red oculography to measure SPEM in 11 neuroleptic-treated schizophrenic patients, 10 drug-free schizophrenic patients, and 11 normals. The most characteristic abnormality was a significant increase in saccadic intrusions during SPEM in schizophrenic patients (p <.001). SPEM gain was reduced in schizophrenic patients (p <.005). No significant effects of neuroleptic treatment on SPEM were found, including analysis of seven patients in whom paired data was available. We also measured SPEM prior to and after caffeine ingestion (10 mg/kg) in 10 normals. We found reduced saccadic interruptions as a result of caffeine ingestion compared with placebo (p ",

author = "Litman, {R. E.} and Hommer, {D. W.} and T. Clem and Rapaport, {M. H.} and Pato, {C. N.} and D. Pickar",

year = "1989",

language = "English (US)",

volume = "25",

pages = "473--478",

journal = "Psychopharmacology Bulletin",

issn = "0048-5764",

publisher = "MedWorks Media LLC",

number = "3",

}

TY - JOUR

T1 - Smooth pursuit eye movements in schizophrenia

T2 - Effects of neuroleptic treatment and caffeine

AU - Litman, R. E.

AU - Hommer, D. W.

AU - Clem, T.

AU - Rapaport, M. H.

AU - Pato, C. N.

AU - Pickar, D.

PY - 1989

Y1 - 1989

N2 - Abnormal smooth pursuit eye movement (SPEM) has been proposed as a trait marker in schizophrenia. We utilized high resolution infra-red oculography to measure SPEM in 11 neuroleptic-treated schizophrenic patients, 10 drug-free schizophrenic patients, and 11 normals. The most characteristic abnormality was a significant increase in saccadic intrusions during SPEM in schizophrenic patients (p <.001). SPEM gain was reduced in schizophrenic patients (p <.005). No significant effects of neuroleptic treatment on SPEM were found, including analysis of seven patients in whom paired data was available. We also measured SPEM prior to and after caffeine ingestion (10 mg/kg) in 10 normals. We found reduced saccadic interruptions as a result of caffeine ingestion compared with placebo (p

AB - Abnormal smooth pursuit eye movement (SPEM) has been proposed as a trait marker in schizophrenia. We utilized high resolution infra-red oculography to measure SPEM in 11 neuroleptic-treated schizophrenic patients, 10 drug-free schizophrenic patients, and 11 normals. The most characteristic abnormality was a significant increase in saccadic intrusions during SPEM in schizophrenic patients (p <.001). SPEM gain was reduced in schizophrenic patients (p <.005). No significant effects of neuroleptic treatment on SPEM were found, including analysis of seven patients in whom paired data was available. We also measured SPEM prior to and after caffeine ingestion (10 mg/kg) in 10 normals. We found reduced saccadic interruptions as a result of caffeine ingestion compared with placebo (p

UR - http://www.scopus.com/inward/record.url?scp=0024797342&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024797342&partnerID=8YFLogxK

M3 - Article

C2 - 2576322

AN - SCOPUS:0024797342

SN - 0048-5764

VL - 25

SP - 473

EP - 478

JO - Psychopharmacology Bulletin

JF - Psychopharmacology Bulletin

IS - 3

ER -

Smooth pursuit eye movements in schizophrenia: Effects of neuroleptic treatment and caffeine

Abstract

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this