Smooth-pursuit eye movements, and diazepam, CPZ, and secobarbital

Philip S. Holzman; Deborah L. Levy; Eberhard H. Uhlenhuth; Leonard R. Proctor; Daniel X. Freedman

doi:10.1007/BF00420996

Smooth-pursuit eye movements, and diazepam, CPZ, and secobarbital

Philip S. Holzman, Deborah L. Levy, Eberhard H. Uhlenhuth, Leonard R. Proctor, Daniel X. Freedman

Research output: Contribution to journal › Article › peer-review

Abstract

This study examined the effects on smooth-pursuit eye tracking of single doses of CPZ (0.667 and 1.334 mg/kg), diazepam (0.071, 0.142, and 0.284 mg/kg), and secobarbital (100 mg). Only the barbiturate significantly affected the ability to follow a moving target with smooth-pursuit eye movements. In repeated testing of a single subject, 130 mg of secobarbital disrupted smooth-pursuit movements at least until 24 hrs after ingestion.

Original language	English (US)
Pages (from-to)	111-115
Number of pages	5
Journal	Psychopharmacologia
Volume	44
Issue number	2
DOIs	https://doi.org/10.1007/BF00420996
State	Published - Jan 1975
Externally published	Yes

Keywords

Chlorpromazine
Diazepam
Eye Tracking
Schizophrenia
Secobarbital
Smooth Pursuit

ASJC Scopus subject areas

Pharmacology

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10.1007/BF00420996

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title = "Smooth-pursuit eye movements, and diazepam, CPZ, and secobarbital",

abstract = "This study examined the effects on smooth-pursuit eye tracking of single doses of CPZ (0.667 and 1.334 mg/kg), diazepam (0.071, 0.142, and 0.284 mg/kg), and secobarbital (100 mg). Only the barbiturate significantly affected the ability to follow a moving target with smooth-pursuit eye movements. In repeated testing of a single subject, 130 mg of secobarbital disrupted smooth-pursuit movements at least until 24 hrs after ingestion.",

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AU - Levy, Deborah L.

AU - Uhlenhuth, Eberhard H.

AU - Proctor, Leonard R.

AU - Freedman, Daniel X.

PY - 1975/1

Y1 - 1975/1

N2 - This study examined the effects on smooth-pursuit eye tracking of single doses of CPZ (0.667 and 1.334 mg/kg), diazepam (0.071, 0.142, and 0.284 mg/kg), and secobarbital (100 mg). Only the barbiturate significantly affected the ability to follow a moving target with smooth-pursuit eye movements. In repeated testing of a single subject, 130 mg of secobarbital disrupted smooth-pursuit movements at least until 24 hrs after ingestion.

AB - This study examined the effects on smooth-pursuit eye tracking of single doses of CPZ (0.667 and 1.334 mg/kg), diazepam (0.071, 0.142, and 0.284 mg/kg), and secobarbital (100 mg). Only the barbiturate significantly affected the ability to follow a moving target with smooth-pursuit eye movements. In repeated testing of a single subject, 130 mg of secobarbital disrupted smooth-pursuit movements at least until 24 hrs after ingestion.

KW - Chlorpromazine

KW - Diazepam

KW - Eye Tracking

KW - Schizophrenia

KW - Secobarbital

KW - Smooth Pursuit

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Smooth-pursuit eye movements, and diazepam, CPZ, and secobarbital

Abstract

Keywords

ASJC Scopus subject areas

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