Smoking without nicotine delivery decreases withdrawal in 12-hour abstinent smokers

Marsha F. Butschky, Denise Bailey, Jack E. Henningfield, Wallace B. Pickworth

Research output: Contribution to journalArticlepeer-review

117 Scopus citations


The contribution of sensory factors to smoking satisfaction and nicotine withdrawal symptoms was assessed by evaluating responses to three types of cigarettes: a regular cigarette, a de-nicotinized cigarette (de-nic), and a lettuce leaf cigarette. Doses were varied by requiring subjects to smoke cigarettes using a five-port cigarette manifold. The ratio of the regular or de-nic cigarettes to the lettuce cigarettes was varied across the following values: zero, one, two, and four of five. Seven male smokers were tobacco-deprived for 12 h before testing. On one test day they smoked the de-nic cigarettes, and on another day they smoked the regular cigarettes. Ratings of satisfaction and cigarette liking were directly related to the number of regular or de-nic cigarettes, but were generally higher after the regular cigarette. The regular and de-nic cigarettes were equivalent in reducing acute withdrawal symptoms. Expired CO was similar on both experimental days. The regular cigarette dose-dependently increased plasma nicotine, but the de-nic cigarette did not increase plasma nicotine. These results indicate that sensory characteristics of cigarettes contribute to the abuse liability of smoke-delivered nicotine. The results suggest that smoking cigarettes that do not provide nicotine may temporarily suppress cigarette withdrawal symptoms.

Original languageEnglish (US)
Pages (from-to)91-96
Number of pages6
JournalPharmacology, Biochemistry and Behavior
Issue number1
StatePublished - Jan 1995
Externally publishedYes


  • De-nicotinized cigarette
  • Sensory factors
  • Smoking behavior
  • Tobacco withdrawal

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience


Dive into the research topics of 'Smoking without nicotine delivery decreases withdrawal in 12-hour abstinent smokers'. Together they form a unique fingerprint.

Cite this