Small changes in expression affect predisposition to tumorigenesis

Hai Yan, Zuzana Dobbie, Stephen B. Gruber, Sanford Markowitz, Kathy Romans, Francis M. Giardiello, Kenneth W. Kinzler, Bert Vogelstein

Research output: Contribution to journalArticlepeer-review

185 Scopus citations


We have used quantitative measures of gene expression to show that constitutional 50% decreases in expression of one adenomatous polyposis coli tumor suppressor gene (APC) allele can lead to the development of familial adenomatous polyposis.

Original languageEnglish (US)
Pages (from-to)25-26
Number of pages2
JournalNature genetics
Issue number1
StatePublished - Jan 2002

ASJC Scopus subject areas

  • Genetics


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