Small changes in expression affect predisposition to tumorigenesis

Hai Yan; Zuzana Dobbie; Stephen B. Gruber; Sanford Markowitz; Kathy Romans; Francis M. Giardiello; Kenneth W. Kinzler; Bert Vogelstein

doi:10.1038/ng799

Small changes in expression affect predisposition to tumorigenesis

Hai Yan, Zuzana Dobbie, Stephen B. Gruber, Sanford Markowitz, Kathy Romans, Francis M. Giardiello, Kenneth W. Kinzler, Bert Vogelstein

School of Medicine

Research output: Contribution to journal › Article › peer-review

185 Scopus citations

Abstract

We have used quantitative measures of gene expression to show that constitutional 50% decreases in expression of one adenomatous polyposis coli tumor suppressor gene (APC) allele can lead to the development of familial adenomatous polyposis.

Original language	English (US)
Pages (from-to)	25-26
Number of pages	2
Journal	Nature genetics
Volume	30
Issue number	1
DOIs	https://doi.org/10.1038/ng799
State	Published - Jan 2002

ASJC Scopus subject areas

Genetics

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title = "Small changes in expression affect predisposition to tumorigenesis",

abstract = "We have used quantitative measures of gene expression to show that constitutional 50% decreases in expression of one adenomatous polyposis coli tumor suppressor gene (APC) allele can lead to the development of familial adenomatous polyposis.",

author = "Hai Yan and Zuzana Dobbie and Gruber, {Stephen B.} and Sanford Markowitz and Kathy Romans and Giardiello, {Francis M.} and Kinzler, {Kenneth W.} and Bert Vogelstein",

note = "Funding Information: This work was supported by grants from the National Institutes of Health.",

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AU - Yan, Hai

AU - Dobbie, Zuzana

AU - Gruber, Stephen B.

AU - Markowitz, Sanford

AU - Romans, Kathy

AU - Giardiello, Francis M.

AU - Kinzler, Kenneth W.

AU - Vogelstein, Bert

N1 - Funding Information: This work was supported by grants from the National Institutes of Health.

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Small changes in expression affect predisposition to tumorigenesis

Abstract

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