Small bowel obstruction after floseal use

Benjamin Clapp, Antonio Santillan

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Objective: FloSeal is a thrombin-gelatin hemostatic matrix that is used to obtain hemostasis. There have been isolated case reports of FloSeal causing bowel obstructions, requiring surgical intervention. We report 3 cases of what we believe were FloSeal-induced small bowel obstructions (SBO). Methods: We present a series of small bowel obstructions after FloSeal use. Our series includes urology, gynecologic oncology, and general surgery cases at the same institution where the product was appropriately used and resulted in the same complication. Results: FloSeal was used for hemostasis in all patients. In each instance, a small bowel obstruction developed in 7 days to 9 days. All patients were reexplored laparoscopically and found to have an intense inflammatory reaction at the site of the FloSeal. The adhesions were lysed and the obstructions resolved. Conclusions: Although further study is needed, the common factor in all these SBOs was a hemostatic agent. In our and others' series, the time to SBO was 7 days to 9 days. If an early postoperative SBO occurs after FloSeal is used, prompt reexploration should be considered.

Original languageEnglish (US)
Pages (from-to)361-364
Number of pages4
JournalJournal of the Society of Laparoendoscopic Surgeons
Issue number3
StatePublished - Jul 2011
Externally publishedYes


  • Floseal
  • Hemostatic agents
  • Small bowel obstruction

ASJC Scopus subject areas

  • Surgery


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