TY - JOUR
T1 - SlimQuick™- associated hepatotoxicity in a woman with alpha-1 antitrypsin heterozygosity
AU - Weinstein, Douglas H.
AU - Twaddell, William S.
AU - Raufman, Jean Pierre
AU - Philosophe, Benjamin
AU - Mindikoglu, Ayse L.
PY - 2012
Y1 - 2012
N2 - Green tea (Camellia sinensis)-associated hepatotoxicity is reported. However, the presence of alpha-1 antitrypsin MZ phenotype as a predisposing factor to green tea-associated drug-induced liver injury (DILI) is unknown. A previously healthy woman with alpha-1 antitrypsin MZ phenotype who took SlimQuick ™, an herbal supplement containing green tea extract, developed severe hepatotoxicity requiring corticosteroid treatment. Green tea-associated hepatotoxicity is reviewed and alpha-1 antitrypsin MZ phenotype as a predisposing factor to green tea-associated DILI is discussed. Liver biopsy demonstrated marked inflammation with necrosis suggestive of toxic injury with diffuse alpha-1 antitrypsin globule deposition on immunostaining. Corticosteroid therapy resulted in rapid clinical improvement. Alpha-1 antitrypsin MZ phenotype may increase vulnerability to herbal hepatotoxicity.
AB - Green tea (Camellia sinensis)-associated hepatotoxicity is reported. However, the presence of alpha-1 antitrypsin MZ phenotype as a predisposing factor to green tea-associated drug-induced liver injury (DILI) is unknown. A previously healthy woman with alpha-1 antitrypsin MZ phenotype who took SlimQuick ™, an herbal supplement containing green tea extract, developed severe hepatotoxicity requiring corticosteroid treatment. Green tea-associated hepatotoxicity is reviewed and alpha-1 antitrypsin MZ phenotype as a predisposing factor to green tea-associated DILI is discussed. Liver biopsy demonstrated marked inflammation with necrosis suggestive of toxic injury with diffuse alpha-1 antitrypsin globule deposition on immunostaining. Corticosteroid therapy resulted in rapid clinical improvement. Alpha-1 antitrypsin MZ phenotype may increase vulnerability to herbal hepatotoxicity.
KW - Alpha-1-antitrypsin MZ phenotype
KW - Drug-induced liver injury
KW - Green tea
KW - Hepatotoxicity
KW - SlimQuick™
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UR - http://www.scopus.com/inward/citedby.url?scp=84876533957&partnerID=8YFLogxK
U2 - 10.4254/wjh.v4.i4.154
DO - 10.4254/wjh.v4.i4.154
M3 - Article
C2 - 22567188
AN - SCOPUS:84876533957
SN - 1948-5182
VL - 4
SP - 154
EP - 157
JO - World Journal of Hepatology
JF - World Journal of Hepatology
IS - 4
ER -