Sleep apnea research in animals: Past, present, and future

Swati Chopra, Vsevolod Y. Polotsky, Jonathan C. Jun

Research output: Contribution to journalReview articlepeer-review

33 Scopus citations


Obstructive sleep apnea (OSA) is a common disorder that describes recurrent collapse of theupper airway during sleep.Animalmodelshave been pivotal to the understanding of OSA pathogenesis, consequences, and treatment. In this review, we highlight the history of OSA research in animals and include the discovery of animalswith spontaneous OSA, the induction of OSA in animals, and the emulation of OSA using exposures to intermittent hypoxia and sleep fragmentation.

Original languageEnglish (US)
Pages (from-to)299-305
Number of pages7
JournalAmerican journal of respiratory cell and molecular biology
Issue number3
StatePublished - Mar 2016


  • Animal
  • Fragmentation
  • Intermittent hypoxia
  • Sleep apnea

ASJC Scopus subject areas

  • Molecular Biology
  • Pulmonary and Respiratory Medicine
  • Clinical Biochemistry
  • Cell Biology


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