Sleep apnea research in animals: Past, present, and future

Swati Chopra; Vsevolod Y. Polotsky; Jonathan C. Jun

doi:10.1165/rcmb.2015-0218TR

Sleep apnea research in animals: Past, present, and future

Swati Chopra, Vsevolod Y. Polotsky, Jonathan C. Jun

School of Medicine

Research output: Contribution to journal › Review article › peer-review

33 Scopus citations

Abstract

Obstructive sleep apnea (OSA) is a common disorder that describes recurrent collapse of theupper airway during sleep.Animalmodelshave been pivotal to the understanding of OSA pathogenesis, consequences, and treatment. In this review, we highlight the history of OSA research in animals and include the discovery of animalswith spontaneous OSA, the induction of OSA in animals, and the emulation of OSA using exposures to intermittent hypoxia and sleep fragmentation.

Original language	English (US)
Pages (from-to)	299-305
Number of pages	7
Journal	American journal of respiratory cell and molecular biology
Volume	54
Issue number	3
DOIs	https://doi.org/10.1165/rcmb.2015-0218TR
State	Published - Mar 2016

Keywords

Animal
Fragmentation
Intermittent hypoxia
Sleep apnea

ASJC Scopus subject areas

Molecular Biology
Pulmonary and Respiratory Medicine
Clinical Biochemistry
Cell Biology

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10.1165/rcmb.2015-0218TR

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abstract = "Obstructive sleep apnea (OSA) is a common disorder that describes recurrent collapse of theupper airway during sleep.Animalmodelshave been pivotal to the understanding of OSA pathogenesis, consequences, and treatment. In this review, we highlight the history of OSA research in animals and include the discovery of animalswith spontaneous OSA, the induction of OSA in animals, and the emulation of OSA using exposures to intermittent hypoxia and sleep fragmentation.",

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AB - Obstructive sleep apnea (OSA) is a common disorder that describes recurrent collapse of theupper airway during sleep.Animalmodelshave been pivotal to the understanding of OSA pathogenesis, consequences, and treatment. In this review, we highlight the history of OSA research in animals and include the discovery of animalswith spontaneous OSA, the induction of OSA in animals, and the emulation of OSA using exposures to intermittent hypoxia and sleep fragmentation.

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KW - Fragmentation

KW - Intermittent hypoxia

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Sleep apnea research in animals: Past, present, and future

Abstract

Keywords

ASJC Scopus subject areas

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