Abstract
Background - Recently, several studies have shown an alteration in bowel function during sleep in patients with irritable bowel syndrome (IBS), and a recent study also suggests a remarkable increase in rapid eye movement (REM) sleep. These studies have suggested that an alteration in CNS function may play an important role in the pathogenesis of IBS. Aims - To confirm the presence of an alteration in REM sleep in patients with IBS and to assess the relation between sleep and a non-invasive measure of gastric functioning, the electrogastrogram (EGG). Patients - Ten patients with IBSand 10 age and sex matched normal volunteers. Methods-All subjects slept one night in the sleep laboratory and underwent polysomnographic monitoring to determine sleep patterns, and recording of the EGG from surface electrodes. Results - The IBS group had a notable and significant increase in the percentage and duration of REM sleep (p<0.05). The control group had a decrease in the amplitude of the dominant EGG frequency from waking to non-REM sleep (p<0.05), and a subsequent increase in the amplitude from non-REM to REM sleep (p<0.05). No such changes were noted in the patients with IBS. Conclusions - Results confirmed the enhancement of REM sleep in patients with lBS and suggested an intrinsic alteration in autonomic and CNS functioning in patients with IBS.
Original language | English (US) |
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Pages (from-to) | 390-393 |
Number of pages | 4 |
Journal | Gut |
Volume | 41 |
Issue number | 3 |
DOIs | |
State | Published - 1997 |
Externally published | Yes |
Keywords
- Brain/gut
- Gastric function
- Irritable bowel syndrome
- Sleep
ASJC Scopus subject areas
- Gastroenterology