Skin tissue repair: Matrix microenvironmental influences

Alan Wells, Austin Nuschke, Cecelia C. Yates

Research output: Contribution to journalReview articlepeer-review


The process of repair of wounded skin involves intricate orchestration not only between the epidermal and dermal compartments but also between the resident and immigrant cells and the local microenvironment. Only now are we beginning to appreciate the complex roles played by the matrix in directing the outcome of the repair processes, and how this impacts the signals from the various cells. Recent findings speak of dynamic and reciprocal interactions that occurs among the matrix, growth factors, and cells that underlies this integrated process. Further confounding this integration are the physiologic and pathologic situations that directly alter the matrix to impart at least part of the dysrepair that occurs. These topics will be discussed with a call for innovative model systems of direct relevance to the human situation.

Original languageEnglish (US)
Pages (from-to)25-36
Number of pages12
JournalMatrix Biology
StatePublished - Jan 1 2016
Externally publishedYes


  • Chronic wound
  • Collagen
  • Decorin
  • Extracellular matrix
  • Matrikine signaling
  • Skin organ cultures
  • Tenascin-C
  • Wound healing

ASJC Scopus subject areas

  • Molecular Biology


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