Raynaud’s phenomenon presents clinically as cold mottled skin and most commonly involves the extremities. It results from vasoconstriction of the superficial thermoregulatory vessels as an exaggerated response to cold temperatures and/or to stress. It can occur primarily, without an associated autoimmune disease, or can relate to underlying rheumatic diseases such as scleroderma or mixed connective tissue disease.
ASJC Scopus subject areas
- General Medicine