TY - JOUR
T1 - Size of the Physiologic Cup of the Optic Nerve Head
T2 - Hereditary and Environmental Factors
AU - Schwartz, J. Theodore
AU - Reuling, Frank H.
AU - Feinleib, Manning
PY - 1975
Y1 - 1975
N2 - This study provides a quantitative assessment of heritability of size of the normal physiologic cup when estimated as a continuous variable. A horizontal cupdisc ratio was estimated clinically among a sample of 37 pairs of monozygotic (MZ) and 26 pairs of like-sexed dizygotic (DZ) twins. Differences in intrapair variance and intraclass correlation coefficient between the MZ and the DZ samples were large and highly significant, and suggest that inheritance plays a major role in determining diameter of the normal physiologic cup. Values of heritability index (HI, an estimate of the proportion of variance within pairs explained by genetic factors) ranged from 0.60 to 0.80 by various computational methods employed.
AB - This study provides a quantitative assessment of heritability of size of the normal physiologic cup when estimated as a continuous variable. A horizontal cupdisc ratio was estimated clinically among a sample of 37 pairs of monozygotic (MZ) and 26 pairs of like-sexed dizygotic (DZ) twins. Differences in intrapair variance and intraclass correlation coefficient between the MZ and the DZ samples were large and highly significant, and suggest that inheritance plays a major role in determining diameter of the normal physiologic cup. Values of heritability index (HI, an estimate of the proportion of variance within pairs explained by genetic factors) ranged from 0.60 to 0.80 by various computational methods employed.
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U2 - 10.1001/archopht.1975.01010020670002
DO - 10.1001/archopht.1975.01010020670002
M3 - Article
C2 - 1235482
AN - SCOPUS:0016729013
SN - 0003-9950
VL - 93
SP - 776
EP - 780
JO - Archives of Ophthalmology
JF - Archives of Ophthalmology
IS - 9
ER -