Sirtuin 1 activator SRT2104 protects Huntington's disease mice

Mali Jiang; Jennifer Zheng; Qi Peng; Zhipeng Hou; Jiangyang Zhang; Susumu Mori; James L. Ellis; George P. Vlasuk; Harvey Fries; Vipin Suri; Wenzhen Duan

doi:10.1002/acn3.135

Sirtuin 1 activator SRT2104 protects Huntington's disease mice

Mali Jiang, Jennifer Zheng, Qi Peng, Zhipeng Hou, Jiangyang Zhang, Susumu Mori, James L. Ellis, George P. Vlasuk, Harvey Fries, Vipin Suri, Wenzhen Duan

School of Medicine

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Sirtuin 1 is a nicotinamide adenine dinucleotide-dependent protein deacetylase which regulates longevity and improves metabolism. Activation of Sirtuin 1 confers beneficial effects in models of neurodegenerative diseases. We and others have provided convincing evidence that overexpression of Sirtuin 1 plays a neuroprotective role in mouse models of Huntington's disease. In this study, we report that SRT2104, a small molecule Sirtuin 1 activator, penetrated the blood–brain barrier, attenuated brain atrophy, improved motor function, and extended survival in a mouse model of Huntington's disease. These findings imply a novel therapeutic strategy for Huntington's disease by targeting Sirtuin 1.

Original language	English (US)
Pages (from-to)	1047-1052
Number of pages	6
Journal	Annals of Clinical and Translational Neurology
Volume	1
Issue number	12
DOIs	https://doi.org/10.1002/acn3.135
State	Published - Dec 2014

ASJC Scopus subject areas

Neuroscience(all)
Clinical Neurology

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title = "Sirtuin 1 activator SRT2104 protects Huntington's disease mice",

abstract = "Sirtuin 1 is a nicotinamide adenine dinucleotide-dependent protein deacetylase which regulates longevity and improves metabolism. Activation of Sirtuin 1 confers beneficial effects in models of neurodegenerative diseases. We and others have provided convincing evidence that overexpression of Sirtuin 1 plays a neuroprotective role in mouse models of Huntington's disease. In this study, we report that SRT2104, a small molecule Sirtuin 1 activator, penetrated the blood–brain barrier, attenuated brain atrophy, improved motor function, and extended survival in a mouse model of Huntington's disease. These findings imply a novel therapeutic strategy for Huntington's disease by targeting Sirtuin 1.",

author = "Mali Jiang and Jennifer Zheng and Qi Peng and Zhipeng Hou and Jiangyang Zhang and Susumu Mori and Ellis, {James L.} and Vlasuk, {George P.} and Harvey Fries and Vipin Suri and Wenzhen Duan",

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AU - Jiang, Mali

AU - Zheng, Jennifer

AU - Peng, Qi

AU - Hou, Zhipeng

AU - Zhang, Jiangyang

AU - Mori, Susumu

AU - Ellis, James L.

AU - Vlasuk, George P.

AU - Fries, Harvey

AU - Suri, Vipin

AU - Duan, Wenzhen

PY - 2014/12

Y1 - 2014/12

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AB - Sirtuin 1 is a nicotinamide adenine dinucleotide-dependent protein deacetylase which regulates longevity and improves metabolism. Activation of Sirtuin 1 confers beneficial effects in models of neurodegenerative diseases. We and others have provided convincing evidence that overexpression of Sirtuin 1 plays a neuroprotective role in mouse models of Huntington's disease. In this study, we report that SRT2104, a small molecule Sirtuin 1 activator, penetrated the blood–brain barrier, attenuated brain atrophy, improved motor function, and extended survival in a mouse model of Huntington's disease. These findings imply a novel therapeutic strategy for Huntington's disease by targeting Sirtuin 1.

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Sirtuin 1 activator SRT2104 protects Huntington's disease mice

Abstract

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