Abstract
Sirtuin 1 is a nicotinamide adenine dinucleotide-dependent protein deacetylase which regulates longevity and improves metabolism. Activation of Sirtuin 1 confers beneficial effects in models of neurodegenerative diseases. We and others have provided convincing evidence that overexpression of Sirtuin 1 plays a neuroprotective role in mouse models of Huntington's disease. In this study, we report that SRT2104, a small molecule Sirtuin 1 activator, penetrated the blood–brain barrier, attenuated brain atrophy, improved motor function, and extended survival in a mouse model of Huntington's disease. These findings imply a novel therapeutic strategy for Huntington's disease by targeting Sirtuin 1.
Original language | English (US) |
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Pages (from-to) | 1047-1052 |
Number of pages | 6 |
Journal | Annals of Clinical and Translational Neurology |
Volume | 1 |
Issue number | 12 |
DOIs | |
State | Published - Dec 2014 |
ASJC Scopus subject areas
- General Neuroscience
- Clinical Neurology