Sirtuin 1 activator SRT2104 protects Huntington's disease mice

Mali Jiang; Jennifer Zheng; Qi Peng; Zhipeng Hou; Jiangyang Zhang; Susumu Mori; James L. Ellis; George P. Vlasuk; Harvey Fries; Vipin Suri; Wenzhen Duan

doi:10.1002/acn3.135

Sirtuin 1 activator SRT2104 protects Huntington's disease mice

Mali Jiang, Jennifer Zheng, Qi Peng, Zhipeng Hou, Jiangyang Zhang, Susumu Mori, James L. Ellis, George P. Vlasuk, Harvey Fries, Vipin Suri, Wenzhen Duan

School of Medicine

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Sirtuin 1 is a nicotinamide adenine dinucleotide-dependent protein deacetylase which regulates longevity and improves metabolism. Activation of Sirtuin 1 confers beneficial effects in models of neurodegenerative diseases. We and others have provided convincing evidence that overexpression of Sirtuin 1 plays a neuroprotective role in mouse models of Huntington's disease. In this study, we report that SRT2104, a small molecule Sirtuin 1 activator, penetrated the blood–brain barrier, attenuated brain atrophy, improved motor function, and extended survival in a mouse model of Huntington's disease. These findings imply a novel therapeutic strategy for Huntington's disease by targeting Sirtuin 1.

Original language	English (US)
Pages (from-to)	1047-1052
Number of pages	6
Journal	Annals of Clinical and Translational Neurology
Volume	1
Issue number	12
DOIs	https://doi.org/10.1002/acn3.135
State	Published - Dec 2014

ASJC Scopus subject areas

General Neuroscience
Clinical Neurology

Access to Document

10.1002/acn3.135

Cite this

@article{f8ccdc65dfd64a1e8d7a21276a87eba9,

title = "Sirtuin 1 activator SRT2104 protects Huntington's disease mice",

abstract = "Sirtuin 1 is a nicotinamide adenine dinucleotide-dependent protein deacetylase which regulates longevity and improves metabolism. Activation of Sirtuin 1 confers beneficial effects in models of neurodegenerative diseases. We and others have provided convincing evidence that overexpression of Sirtuin 1 plays a neuroprotective role in mouse models of Huntington's disease. In this study, we report that SRT2104, a small molecule Sirtuin 1 activator, penetrated the blood–brain barrier, attenuated brain atrophy, improved motor function, and extended survival in a mouse model of Huntington's disease. These findings imply a novel therapeutic strategy for Huntington's disease by targeting Sirtuin 1.",

author = "Mali Jiang and Jennifer Zheng and Qi Peng and Zhipeng Hou and Jiangyang Zhang and Susumu Mori and Ellis, {James L.} and Vlasuk, {George P.} and Harvey Fries and Vipin Suri and Wenzhen Duan",

note = "Publisher Copyright: {\textcopyright} 2014 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.",

year = "2014",

month = dec,

doi = "10.1002/acn3.135",

language = "English (US)",

volume = "1",

pages = "1047--1052",

journal = "Annals of Clinical and Translational Neurology",

issn = "2328-9503",

publisher = "John Wiley & Sons Inc.",

number = "12",

}

TY - JOUR

T1 - Sirtuin 1 activator SRT2104 protects Huntington's disease mice

AU - Jiang, Mali

AU - Zheng, Jennifer

AU - Peng, Qi

AU - Hou, Zhipeng

AU - Zhang, Jiangyang

AU - Mori, Susumu

AU - Ellis, James L.

AU - Vlasuk, George P.

AU - Fries, Harvey

AU - Suri, Vipin

AU - Duan, Wenzhen

PY - 2014/12

Y1 - 2014/12

N2 - Sirtuin 1 is a nicotinamide adenine dinucleotide-dependent protein deacetylase which regulates longevity and improves metabolism. Activation of Sirtuin 1 confers beneficial effects in models of neurodegenerative diseases. We and others have provided convincing evidence that overexpression of Sirtuin 1 plays a neuroprotective role in mouse models of Huntington's disease. In this study, we report that SRT2104, a small molecule Sirtuin 1 activator, penetrated the blood–brain barrier, attenuated brain atrophy, improved motor function, and extended survival in a mouse model of Huntington's disease. These findings imply a novel therapeutic strategy for Huntington's disease by targeting Sirtuin 1.

AB - Sirtuin 1 is a nicotinamide adenine dinucleotide-dependent protein deacetylase which regulates longevity and improves metabolism. Activation of Sirtuin 1 confers beneficial effects in models of neurodegenerative diseases. We and others have provided convincing evidence that overexpression of Sirtuin 1 plays a neuroprotective role in mouse models of Huntington's disease. In this study, we report that SRT2104, a small molecule Sirtuin 1 activator, penetrated the blood–brain barrier, attenuated brain atrophy, improved motor function, and extended survival in a mouse model of Huntington's disease. These findings imply a novel therapeutic strategy for Huntington's disease by targeting Sirtuin 1.

UR - http://www.scopus.com/inward/record.url?scp=84938685650&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84938685650&partnerID=8YFLogxK

U2 - 10.1002/acn3.135

DO - 10.1002/acn3.135

M3 - Article

AN - SCOPUS:84938685650

SN - 2328-9503

VL - 1

SP - 1047

EP - 1052

JO - Annals of Clinical and Translational Neurology

JF - Annals of Clinical and Translational Neurology

IS - 12

ER -

Sirtuin 1 activator SRT2104 protects Huntington's disease mice

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this