Sinonasal eosinophilic angiocentric fibrosis: A systematic review

Christina H. Fang, Leila J. Mady, Neena M. Mirani, Soly Baredes, Jean Anderson Eloy

Research output: Contribution to journalReview articlepeer-review


Background: Eosinophilic angiocentric fibrosis (EAF) is a benign rare lesion of the upper respiratory mucosa. EAF most commonly presents with an obstructive nasal mass. Due to the rarity of EAF, case reports and case studies have predominated the literature. This systematic review discusses the demographics, clinical presentation, associated findings, management, and outcomes of this uncommon entity. Methods: The PubMed database was searched for all articles describing patients diagnosed with sinonasal EAF. Additional cases were examined from the bibliographies of selected articles. Demographics, clinical presentation, associated findings, radiography, management, and outcome were analyzed. Results: Fifty-two cases were included from 34 articles, including 1 case from our institution. The most common presenting symptom was nasal obstruction (78.8%). Fourteen patients (26.9%) had a previous history of nasal surgery or trauma. Surgical resection alone was the most commonly used primary treatment approach (50.0%), resulting in the greatest proportion of disease-free patients (55.6%) over a median follow-up period of 36 months. A combination of surgery and corticosteroids was the second-most-common treatment modality, used in 28.8% of cases. Of the 40 cases reporting patient outcomes, 100% of patients were alive at follow-up independent of treatment modality. Conclusion: To date, this review contains the largest number of patients with sinonasal EAF. Aggressive surgical resection alone constitutes the most common treatment modality and may be most effective at eradicating disease.

Original languageEnglish (US)
Pages (from-to)745-752
Number of pages8
JournalInternational Forum of Allergy and Rhinology
Issue number9
StatePublished - Sep 2014
Externally publishedYes


  • Angiocentric fibrosis
  • Eosinophilic angiocentric fibrosis
  • Nasal eosinophilic angiocentric fibrosis
  • Sinonasal mass
  • Sinus
  • Sinus eosinophilic angiocentric fibrosis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Otorhinolaryngology


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