TY - JOUR
T1 - Single-trial speech suppression of auditory cortex activity in humans
AU - Flinker, Adeen
AU - Chang, Edward F.
AU - Kirsch, Heidi E.
AU - Barbaro, Nicholas M.
AU - Crone, Nathan E.
AU - Knight, Robert T.
PY - 2010/12/8
Y1 - 2010/12/8
N2 - The human auditory cortex is engaged in monitoring the speech of interlocutors as well as self-generated speech. During vocalization, auditory cortex activity is reported to be suppressed, an effect often attributed to the influence of an efference copy from motor cortex. Single-unit studies in non-human primates have demonstrated a rich dynamic range of single-trial auditory responses to self-speech consisting of suppressed, nonsuppressed and excited auditory neurons. However, human research using noninvasive methods has only reported suppression of averaged auditory cortex responses to self-generated speech. We addressed this discrepancy by recording electrocorticographic activity from neurosurgical subjects performing auditory repetition tasks. We observed that the degree of suppression varied across different regions of auditory cortex, revealing a variety of suppressed and nonsuppressed responses during vocalization. Importantly, single-trial high-gamma power (γHigh, 70-150 Hz) robustly tracked individual auditory events and exhibited stable responses across trials for suppressed and nonsuppressed regions.
AB - The human auditory cortex is engaged in monitoring the speech of interlocutors as well as self-generated speech. During vocalization, auditory cortex activity is reported to be suppressed, an effect often attributed to the influence of an efference copy from motor cortex. Single-unit studies in non-human primates have demonstrated a rich dynamic range of single-trial auditory responses to self-speech consisting of suppressed, nonsuppressed and excited auditory neurons. However, human research using noninvasive methods has only reported suppression of averaged auditory cortex responses to self-generated speech. We addressed this discrepancy by recording electrocorticographic activity from neurosurgical subjects performing auditory repetition tasks. We observed that the degree of suppression varied across different regions of auditory cortex, revealing a variety of suppressed and nonsuppressed responses during vocalization. Importantly, single-trial high-gamma power (γHigh, 70-150 Hz) robustly tracked individual auditory events and exhibited stable responses across trials for suppressed and nonsuppressed regions.
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U2 - 10.1523/JNEUROSCI.1809-10.2010
DO - 10.1523/JNEUROSCI.1809-10.2010
M3 - Article
C2 - 21148003
AN - SCOPUS:78650037622
SN - 0270-6474
VL - 30
SP - 16643
EP - 16650
JO - Journal of Neuroscience
JF - Journal of Neuroscience
IS - 49
ER -