TY - JOUR
T1 - Single Round of Antigen Receptor Signaling Programs Naive B Cells to Receive T Cell Help
AU - Damdinsuren, Bazarragchaa
AU - Zhang, Yongqing
AU - Khalil, Ashraf
AU - Wood William H., III H.
AU - Becker, Kevin G.
AU - Shlomchik, Mark J.
AU - Sen, Ranjan
PY - 2010/3
Y1 - 2010/3
N2 - To simulate transient B cell activation that is the likely initiator of T-dependent responses, we examined the molecular and functional consequences of a single round of immunoglobulin M (IgM) signaling. This form of activation triggered early cytosolic signaling and the transcription factor NF-κB activation indistinguishably from conventional continuous IgM crosslinking but did not induce G1 progression. However, single round IgM signaling changed the expression of chemokine and chemokine receptor genes implicated in initiating T-dependent responses, as well as accentuated responsiveness to CD40 signaling. Several features of single-round IgM signaling in vitro were recapitulated in B cells after short-term exposure to antigen in vivo. We propose that transient BCR signals prime B cells to receive T cell help by increasing the probability of B-T encounter and creating a cellular environment that is hyper-responsive to CD40 signaling.
AB - To simulate transient B cell activation that is the likely initiator of T-dependent responses, we examined the molecular and functional consequences of a single round of immunoglobulin M (IgM) signaling. This form of activation triggered early cytosolic signaling and the transcription factor NF-κB activation indistinguishably from conventional continuous IgM crosslinking but did not induce G1 progression. However, single round IgM signaling changed the expression of chemokine and chemokine receptor genes implicated in initiating T-dependent responses, as well as accentuated responsiveness to CD40 signaling. Several features of single-round IgM signaling in vitro were recapitulated in B cells after short-term exposure to antigen in vivo. We propose that transient BCR signals prime B cells to receive T cell help by increasing the probability of B-T encounter and creating a cellular environment that is hyper-responsive to CD40 signaling.
KW - MOLIMMUNO
UR - http://www.scopus.com/inward/record.url?scp=77950022062&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77950022062&partnerID=8YFLogxK
U2 - 10.1016/j.immuni.2010.02.013
DO - 10.1016/j.immuni.2010.02.013
M3 - Article
C2 - 20226693
AN - SCOPUS:77950022062
SN - 1074-7613
VL - 32
SP - 355
EP - 366
JO - Immunity
JF - Immunity
IS - 3
ER -