Single-nucleotide polymorphisms in selected cytokine genes and risk of adult glioma

A. V. Brenner; M. A. Butler; S. S. Wang; A. M. Ruder; N. Rothman; P. A. Schulte; S. J. Chanock; H. A. Fine; M. S. Linet; P. D. Inskip

doi:10.1093/carcin/bgm210

Single-nucleotide polymorphisms in selected cytokine genes and risk of adult glioma

A. V. Brenner, M. A. Butler, S. S. Wang, A. M. Ruder, N. Rothman, P. A. Schulte, S. J. Chanock, H. A. Fine, M. S. Linet, P. D. Inskip

School of Medicine

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

A role of immunological factors in glioma etiology is suggested by reports of an inverse relationship with history of allergy or autoimmune disease. To test whether single-nucleotide polymorphisms (SNPs) in cytokine genes were related to risk of adult glioma, we genotyped 11 SNPs in seven cytokine genes within a hospital-based study conducted by the National Cancer Institute and an independent, population-based study by the National Institute for Occupational Safety and Health (overall 756 cases and 1190 controls with blood samples). The IL4 (rs2243248, -1098T>G) and IL6 (rs1800795, -174G>C) polymorphisms were significantly associated with risk of glioma in the pooled analysis (P trend = 0.006 and 0.04, respectively), although these became attenuated after controlling for the false discovery rate (P trend = 0.07 and 0.22, respectively). Our results underscore the importance of pooled analyses in genetic association studies and suggest that SNPs in cytokine genes may influence susceptibility to glioma.

Original language	English (US)
Pages (from-to)	2543-2547
Number of pages	5
Journal	Carcinogenesis
Volume	28
Issue number	12
DOIs	https://doi.org/10.1093/carcin/bgm210
State	Published - Dec 2007

ASJC Scopus subject areas

Cancer Research

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title = "Single-nucleotide polymorphisms in selected cytokine genes and risk of adult glioma",

abstract = "A role of immunological factors in glioma etiology is suggested by reports of an inverse relationship with history of allergy or autoimmune disease. To test whether single-nucleotide polymorphisms (SNPs) in cytokine genes were related to risk of adult glioma, we genotyped 11 SNPs in seven cytokine genes within a hospital-based study conducted by the National Cancer Institute and an independent, population-based study by the National Institute for Occupational Safety and Health (overall 756 cases and 1190 controls with blood samples). The IL4 (rs2243248, -1098T>G) and IL6 (rs1800795, -174G>C) polymorphisms were significantly associated with risk of glioma in the pooled analysis (P trend = 0.006 and 0.04, respectively), although these became attenuated after controlling for the false discovery rate (P trend = 0.07 and 0.22, respectively). Our results underscore the importance of pooled analyses in genetic association studies and suggest that SNPs in cytokine genes may influence susceptibility to glioma.",

author = "Brenner, {A. V.} and Butler, {M. A.} and Wang, {S. S.} and Ruder, {A. M.} and N. Rothman and Schulte, {P. A.} and Chanock, {S. J.} and Fine, {H. A.} and Linet, {M. S.} and Inskip, {P. D.}",

note = "Funding Information: NCI study by Intramural Research program of the National Institutes of Health (National Cancer Institute, Division of Cancer Epidemiology and Genetics). NIOSH study by NIOSH Initiative for Cancer Control for Farmers and in part by Centers for Disease Control and Prevention/NIOSH operating funds.",

year = "2007",

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doi = "10.1093/carcin/bgm210",

language = "English (US)",

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AU - Brenner, A. V.

AU - Butler, M. A.

AU - Wang, S. S.

AU - Ruder, A. M.

AU - Rothman, N.

AU - Schulte, P. A.

AU - Chanock, S. J.

AU - Fine, H. A.

AU - Linet, M. S.

AU - Inskip, P. D.

N1 - Funding Information: NCI study by Intramural Research program of the National Institutes of Health (National Cancer Institute, Division of Cancer Epidemiology and Genetics). NIOSH study by NIOSH Initiative for Cancer Control for Farmers and in part by Centers for Disease Control and Prevention/NIOSH operating funds.

PY - 2007/12

Y1 - 2007/12

N2 - A role of immunological factors in glioma etiology is suggested by reports of an inverse relationship with history of allergy or autoimmune disease. To test whether single-nucleotide polymorphisms (SNPs) in cytokine genes were related to risk of adult glioma, we genotyped 11 SNPs in seven cytokine genes within a hospital-based study conducted by the National Cancer Institute and an independent, population-based study by the National Institute for Occupational Safety and Health (overall 756 cases and 1190 controls with blood samples). The IL4 (rs2243248, -1098T>G) and IL6 (rs1800795, -174G>C) polymorphisms were significantly associated with risk of glioma in the pooled analysis (P trend = 0.006 and 0.04, respectively), although these became attenuated after controlling for the false discovery rate (P trend = 0.07 and 0.22, respectively). Our results underscore the importance of pooled analyses in genetic association studies and suggest that SNPs in cytokine genes may influence susceptibility to glioma.

AB - A role of immunological factors in glioma etiology is suggested by reports of an inverse relationship with history of allergy or autoimmune disease. To test whether single-nucleotide polymorphisms (SNPs) in cytokine genes were related to risk of adult glioma, we genotyped 11 SNPs in seven cytokine genes within a hospital-based study conducted by the National Cancer Institute and an independent, population-based study by the National Institute for Occupational Safety and Health (overall 756 cases and 1190 controls with blood samples). The IL4 (rs2243248, -1098T>G) and IL6 (rs1800795, -174G>C) polymorphisms were significantly associated with risk of glioma in the pooled analysis (P trend = 0.006 and 0.04, respectively), although these became attenuated after controlling for the false discovery rate (P trend = 0.07 and 0.22, respectively). Our results underscore the importance of pooled analyses in genetic association studies and suggest that SNPs in cytokine genes may influence susceptibility to glioma.

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Single-nucleotide polymorphisms in selected cytokine genes and risk of adult glioma

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