Single molecule nanometronome

Chittanon Buranachai; Sean A. McKinney; Taekjip Ha

doi:10.1021/nl052492p

Single molecule nanometronome

Chittanon Buranachai, Sean A. McKinney, Taekjip Ha

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

We constructed a DNA-based nanomechanical device called the nanometronome. Our device is made by introducing complementary single-stranded overhangs at the two arms of the DNA four-way junction. The ticking rates of this stochastic metronome depend on ion concentrations and can be changed by a set of DNA-based switches to deactivate/reactivate the sticky end. Since the device displays clearly distinguishable responses even with a single base pair difference, it may lead to a single molecule sensor of minute sequence differences of a target DNA.

Original language	English (US)
Pages (from-to)	496-500
Number of pages	5
Journal	Nano Letters
Volume	6
Issue number	3
DOIs	https://doi.org/10.1021/nl052492p
State	Published - Mar 2006
Externally published	Yes

ASJC Scopus subject areas

Bioengineering
Chemistry(all)
Materials Science(all)
Condensed Matter Physics
Mechanical Engineering

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10.1021/nl052492p

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AB - We constructed a DNA-based nanomechanical device called the nanometronome. Our device is made by introducing complementary single-stranded overhangs at the two arms of the DNA four-way junction. The ticking rates of this stochastic metronome depend on ion concentrations and can be changed by a set of DNA-based switches to deactivate/reactivate the sticky end. Since the device displays clearly distinguishable responses even with a single base pair difference, it may lead to a single molecule sensor of minute sequence differences of a target DNA.

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Single molecule nanometronome

Abstract

ASJC Scopus subject areas

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