Single-molecule FRET

Taekjip Ha

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Single molecule studies have revolutionized our understanding of how biomolecules work. The ability to watch one molecule at a time reveals not only the average properties detected in ensemble measurements, but can yield the entire distribution of relevant properties, including subpopulations and rare events. Single molecule studies also reveal the time evolution of biochemical reactions, which, if asynchronous, are not observable via ensemble measurements. In the 1970s, for example, the development of the patch-clamp technique enabled the electrical current through a single ion channel to be measured, revealing many properties, including that ion channels are on/off devices.

Original languageEnglish (US)
Pages (from-to)283-284
Number of pages2
JournalSingle Molecules
Issue number4
StatePublished - 2001
Externally publishedYes

ASJC Scopus subject areas

  • General Chemistry
  • Molecular Biology
  • General Biochemistry, Genetics and Molecular Biology
  • Clinical Biochemistry


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