Single-cell analysis of G-protein signal transduction

Terri Clister, Sohum Mehta, Jin Zhang

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


The growing use of fluorescent biosensors to directly probe the spatiotemporal dynamics of biochemical processes in living cells has revolutionized the study of intracellular signaling. In this review, we summarize recent developments in the use of biosensors to illuminate the molecular details of G-protein-coupled receptor (GPCR) signaling pathways, which have long served as the model for our understanding of signal transduction, while also offering our perspectives on the future of this exciting field. Specifically, we highlight several ways in which biosensor-based single-cell analyses are being used to unravel many of the enduring mysteries that surround these diverse signaling pathways.

Original languageEnglish (US)
Pages (from-to)6681-6688
Number of pages8
JournalJournal of Biological Chemistry
Issue number11
StatePublished - Mar 13 2015

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology


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