Sincalide: A Review of Clinical Utility, Proper Infusion Methodology, and Alternative Cholecystogogues

Harvey Ziessman

Research output: Contribution to journalArticlepeer-review


Sincalide (Kinevac) is widely used in conjunction with cholescintigraphy for a variety of clinical indications. Over the years, numerous publications have verified the optimal infusion methodology. Published data and consensus recommendations emphasize that sincalide, 0.02 μg/kg, should be infused over 60 min. Production problems sometimes limit the availability of sincalide. In that case, non-Food and Drug Administration pharmacy-compounded sincalide may serve as an alternative. Fatty meals have also been used. Various illnesses and drugs may inhibit gallbladder contraction. Thus, these drugs should be withheld for 48 h before the study. Sincalide cholescintigraphy is most commonly used to diagnose or exclude chronic acalculous gallbladder disease. The study should preferably be performed as an outpatient procedure.

Original languageEnglish (US)
Pages (from-to)210-212
Number of pages3
JournalJournal of nuclear medicine technology
Issue number3
StatePublished - Sep 1 2019


  • cholescintigraphy
  • chronic acalculous gallbladder disease
  • gallbladder
  • gastrointestinal
  • sincalide

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging


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