Simultaneously Examination of P53 and C-erbB-2 in Gastroscopic Stomach Tissues

Purpose: To investigate the expression of P53 and C-erbB-2 in gastroscopic Stomach Tissues for redounding to early clinical diagnosis and screening high risk population of gastric carcinomas. Methods: We examined simultaneously with immunohistochemical staining ABC in 15 normal mucosa, 16 mild, 15 moderate, 13 severe intestinal metaplasia tissues and 14 gastric carcinoma tissues. Results: Immunohistochemical positive specimens of P53 and C-erbB-2 found in gastric carcinoma tissues were 8/14(57.1%) and 7/14(50%) respectively. The sensitivity and specificity of immunohistochemical positive rate with double expression of C-erbB-2 and P53 were 28.6% and 100%, while that of Complex expression (C-erbB-2 and/or P53) were 84.6% and 88.1% respectively. Conclusions: C-erbB-2 can be used as a label in clinical diagnosis for gastric carcinoma because of the high specificity. Double expressin of C-erbB-2 and P53 can be used in early clinical diagnosis. Complex expression can be used to screen high risk population of gastric carcinomas.