Simultaneous myocardial strain and dark-blood perfusion imaging using a displacement-encoded MRI pulse sequence

Yuan Le, Ashley Stein, Colin Berry, Peter Kellman, Eric E. Bennett, Joni Taylor, Katherine Lucas, Rael Kopace, Christophe Chefd'Hotel, Christine H. Lorenz, Pierre Croisille, Han Wen

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


The purpose of this study is to develop and evaluate a displacement-encoded pulse sequence for simultaneous perfusion and strain imaging. Displacement-encoded images in two to three myocardial slices were repeatedly acquired using a single-shot pulse sequence for 3 to 4 min, which covers a bolus infusion of Gadolinium contrast. The magnitudes of the images were T 1 weighted and provided quantitative measures of perfusion, while the phase maps yielded strain measurements. In an acute coronary occlusion swine protocol (n = 9), segmental perfusion measurements were validated against microsphere reference standard with a linear regression (slope 0.986, R 2 = 0.765, Bland-Altman standard deviation = 0.15 mL/min/g). In a group of ST-elevation myocardial infarction patients (n = 11), the scan success rate was 76%. Short-term contrast washout rate and perfusion are highly correlated (R2 = 0.72), and the pixelwise relationship between circumferential strain and perfusion was better described with a sigmoidal Hill curve than linear functions. This study demonstrates the feasibility of measuring strain and perfusion from a single set of images.

Original languageEnglish (US)
Pages (from-to)787-798
Number of pages12
JournalMagnetic Resonance in Medicine
Issue number3
StatePublished - Sep 2010
Externally publishedYes


  • First pass
  • Ischemia
  • Myocardial perfusion
  • Strain
  • Viability

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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