@article{184334077031497190d730e786f47c88,
title = "Simultaneous edited MRS of GABA, glutathione, and ethanol",
abstract = "The aim of this work was to develop simultaneous edited MRS of γ-aminobutyric acid (GABA), glutathione (GSH), and ethanol (EtOH) using Hadamard encoding and reconstruction of MEGA-edited spectroscopy (HERMES) at 3T. Density-matrix simulations of HERMES were carried out and compared with phantom experiments. In vivo experiments were performed in six healthy volunteers about 30 min after alcohol consumption. Simulations of HERMES showed GABA-, GSH-, and EtOH-edited spectra with low levels of crosstalk and excellent agreement with phantom spectra. In vivo experiments showed well edited GABA signals at 3.0 ppm, GSH at 2.95 ppm, and EtOH at 1.18 ppm in the respective Hadamard combination spectra. Measured integral ratios were 0.082 ± 0.012 for GABA/Cr, 0.037 ± 0.006 for GSH/Cr, and 0.305 ± 0.129 for EtOH/Cr. Simulated, phantom, and in vivo measurements of HERMES show excellent separation of GABA-, GSH-, and EtOH-edited signals with negligible levels of crosstalk. HERMES allows a threefold acceleration of editing while maintaining spectral quality compared with sequentially acquired MEGA-PRESS measurements.",
keywords = "GABA, GSH, HERMES, edited MRS, ethanol",
author = "Saleh, {Muhammad G.} and Min Wang and Mark Mikkelsen and Hui, {Steve C.N.} and Georg Oeltzschner and Jeff Boissoneault and Bethany Stennett and Edden, {Richard A.E.} and Porges, {Eric C.}",
note = "Funding Information: We would like to thank Brent Foster, Genelle Samson, and Joy Keyanni for their contributions to data collection. Research reported in this publication was supported by the National Institute on Alcohol Abuse and Alcoholism and the National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health under award numbers: RAE: R01 EB023963, R01 EB016089, and P41 EB015909; JB and BS: R01AA025337; ECP: K01AA025306. A portion of this work was performed in the McKnight Brain Institute at the National High Magnetic Field Laboratory's AMRIS Facility, which is supported by National Science Foundation Cooperative Agreement No. DMR-1157490* and the State of Florida. This work was supported in part by an NIH award, S10OD021726, for High End Instrumentation. Funding Information: We would like to thank Brent Foster, Genelle Samson, and Joy Keyanni for their contributions to data collection. Research reported in this publication was supported by the National Institute on Alcohol Abuse and Alcoholism and the National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health under award numbers: RAE: R01 EB023963, R01 EB016089, and P41 EB015909; JB and BS: R01AA025337; ECP: K01AA025306. A portion of this work was performed in the McKnight Brain Institute at the National High Magnetic Field Laboratory's AMRIS Facility, which is supported by National Science Foundation Cooperative Agreement No. DMR‐1157490* and the State of Florida. This work was supported in part by an NIH award, S10OD021726, for High End Instrumentation. Publisher Copyright: {\textcopyright} 2020 John Wiley & Sons, Ltd.",
year = "2020",
month = apr,
day = "1",
doi = "10.1002/nbm.4227",
language = "English (US)",
volume = "33",
journal = "NMR in biomedicine",
issn = "0952-3480",
publisher = "John Wiley and Sons Ltd",
number = "4",
}