Simultaneous determination of six compounds in Wen-Pi-Tang-Hab-Wu-Ling-San using an HPLC-DAD method and application in a pharmacokinetic study

Jianbo Chen; Youngho Kim; Yongki Park; Youngjoo Byun; Jongseong Kang

doi:10.1002/jccs.201400488

Simultaneous determination of six compounds in Wen-Pi-Tang-Hab-Wu-Ling-San using an HPLC-DAD method and application in a pharmacokinetic study

Jianbo Chen, Youngho Kim, Yongki Park, Youngjoo Byun, Jongseong Kang

Research output: Contribution to journal › Article › peer-review

Abstract

An HPLC-DAD-method was established for simultaneous determination of 6 main active components in WHW. The method was validated for specificity, accuracy, precision. The developed method was successfully applied to the pharmacokinetics of salvianolic acid B in rat plasma after administration of WHW, Salviae Miltiorrhizae and pure salvianolic acid B. Statistically significant differences in pk parameters of salvianolic acid B.

Original language	English (US)
Pages (from-to)	439-442
Number of pages	4
Journal	Journal of the Chinese Chemical Society
Volume	62
Issue number	5
DOIs	https://doi.org/10.1002/jccs.201400488
State	Published - May 1 2015
Externally published	Yes

Keywords

HPLC-DAD
Pharmacokinetics
Salvianolic acid B
Wen-Pi-Tang-Hab-Wu-Ling-San

ASJC Scopus subject areas

Chemistry(all)

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10.1002/jccs.201400488

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abstract = "An HPLC-DAD-method was established for simultaneous determination of 6 main active components in WHW. The method was validated for specificity, accuracy, precision. The developed method was successfully applied to the pharmacokinetics of salvianolic acid B in rat plasma after administration of WHW, Salviae Miltiorrhizae and pure salvianolic acid B. Statistically significant differences in pk parameters of salvianolic acid B.",

keywords = "HPLC-DAD, Pharmacokinetics, Salvianolic acid B, Wen-Pi-Tang-Hab-Wu-Ling-San",

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year = "2015",

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doi = "10.1002/jccs.201400488",

language = "English (US)",

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T1 - Simultaneous determination of six compounds in Wen-Pi-Tang-Hab-Wu-Ling-San using an HPLC-DAD method and application in a pharmacokinetic study

AU - Chen, Jianbo

AU - Kim, Youngho

AU - Park, Yongki

AU - Byun, Youngjoo

AU - Kang, Jongseong

PY - 2015/5/1

Y1 - 2015/5/1

N2 - An HPLC-DAD-method was established for simultaneous determination of 6 main active components in WHW. The method was validated for specificity, accuracy, precision. The developed method was successfully applied to the pharmacokinetics of salvianolic acid B in rat plasma after administration of WHW, Salviae Miltiorrhizae and pure salvianolic acid B. Statistically significant differences in pk parameters of salvianolic acid B.

AB - An HPLC-DAD-method was established for simultaneous determination of 6 main active components in WHW. The method was validated for specificity, accuracy, precision. The developed method was successfully applied to the pharmacokinetics of salvianolic acid B in rat plasma after administration of WHW, Salviae Miltiorrhizae and pure salvianolic acid B. Statistically significant differences in pk parameters of salvianolic acid B.

KW - HPLC-DAD

KW - Pharmacokinetics

KW - Salvianolic acid B

KW - Wen-Pi-Tang-Hab-Wu-Ling-San

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DO - 10.1002/jccs.201400488

M3 - Article

SN - 0009-4536

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SP - 439

EP - 442

JO - Journal of the Chinese Chemical Society

JF - Journal of the Chinese Chemical Society

IS - 5

ER -

Simultaneous determination of six compounds in Wen-Pi-Tang-Hab-Wu-Ling-San using an HPLC-DAD method and application in a pharmacokinetic study

Abstract

Keywords

ASJC Scopus subject areas

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