TY - GEN
T1 - Simulations of electrical field stimulation of cardiac myocytes during the relative refractory period
AU - Tung, Leslie
AU - Jain, Sandeep K.
PY - 1992/1/1
Y1 - 1992/1/1
N2 - Global stimulation of the heart during defibrillation may be the result of local field stimulation at the cellular level, in which one end of the cell is depolarized while the other end is hyperpolarized. We have formulated a model which describes the spatial and temporal variation of transmembrane potential along the surface membrane of a single cell subjected to a spatially uniform, pulsed electric field. The ability of the applied field to prolong the action potential may be a relevant factor during defibrillation, and we have used the model to determine the extent of prolongation when the waveform is applied during repolarization. Using an S1-S2 protocol, we find that despite the complicated membrane response, 5 msec, rectangular monophasic S2 pulses (with intensity 2.5 times the SI threshold) prolong the action potential as a monotonie function of the Sl-S2 interval. This finding is similar to cellular responses to stimulation by intracellular current injection.
AB - Global stimulation of the heart during defibrillation may be the result of local field stimulation at the cellular level, in which one end of the cell is depolarized while the other end is hyperpolarized. We have formulated a model which describes the spatial and temporal variation of transmembrane potential along the surface membrane of a single cell subjected to a spatially uniform, pulsed electric field. The ability of the applied field to prolong the action potential may be a relevant factor during defibrillation, and we have used the model to determine the extent of prolongation when the waveform is applied during repolarization. Using an S1-S2 protocol, we find that despite the complicated membrane response, 5 msec, rectangular monophasic S2 pulses (with intensity 2.5 times the SI threshold) prolong the action potential as a monotonie function of the Sl-S2 interval. This finding is similar to cellular responses to stimulation by intracellular current injection.
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U2 - 10.1109/IEMBS.1992.5761151
DO - 10.1109/IEMBS.1992.5761151
M3 - Conference contribution
AN - SCOPUS:85066961949
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
SP - 644
EP - 645
BT - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 1992
A2 - Plonsey, Robert
A2 - Coatrieux, Jean Louis
A2 - Laxminarayan, Swamy
A2 - Morucci, Jean Pierre
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 14th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 1992
Y2 - 29 October 1992 through 1 November 1992
ER -