Simulation study of epicardial action potential under normal and ischemic conditions

V. Torres; J. M. Ferrero; M. Monserrat; J. Saiz; J. M. Ferrero; N. V. Thakor

Simulation study of epicardial action potential under normal and ischemic conditions

V. Torres, J. M. Ferrero, M. Monserrat, J. Saiz, J. M. Ferrero, N. V. Thakor

Research output: Contribution to journal › Conference article › peer-review

Abstract

A computer model has been used to simulate the effects of activation of the ATP sensitive K⁺ channels on the action potential morphology and duration of canine-type epicardial myocytes. Simulations were based on a modified version of the Luo-Rudy mammalian action potential model. Our formulation of I_KATP and the transient outward current (I_to) were included in this model. Our results show that the same fraction of open K-ATP channels has a more pronounced effect in epicardium than in endocardium. We conclude that the presence of a prominent outward current in epicardial but not in endocardial myocytes increases the APD reduction produced by the activation of the K-ATP channels and thus contributes to the dispersion of APD observed under ischemic conditions.

Original language	English (US)
Pages (from-to)	501-504
Number of pages	4
Journal	Computers in cardiology
State	Published - 1997
Externally published	Yes
Event	Proceedings of the 1997 24th Annual Meeting on Computers in Cardiology - Lund, Sweden Duration: Sep 7 1997 → Sep 10 1997

ASJC Scopus subject areas

Computer Science Applications
Cardiology and Cardiovascular Medicine

Cite this

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title = "Simulation study of epicardial action potential under normal and ischemic conditions",

abstract = "A computer model has been used to simulate the effects of activation of the ATP sensitive K+ channels on the action potential morphology and duration of canine-type epicardial myocytes. Simulations were based on a modified version of the Luo-Rudy mammalian action potential model. Our formulation of IKATP and the transient outward current (Ito) were included in this model. Our results show that the same fraction of open K-ATP channels has a more pronounced effect in epicardium than in endocardium. We conclude that the presence of a prominent outward current in epicardial but not in endocardial myocytes increases the APD reduction produced by the activation of the K-ATP channels and thus contributes to the dispersion of APD observed under ischemic conditions.",

author = "V. Torres and Ferrero, {J. M.} and M. Monserrat and J. Saiz and Ferrero, {J. M.} and Thakor, {N. V.}",

year = "1997",

language = "English (US)",

pages = "501--504",

journal = "Computers in cardiology",

issn = "0276-6574",

publisher = "IEEE Computer Society",

note = "Proceedings of the 1997 24th Annual Meeting on Computers in Cardiology ; Conference date: 07-09-1997 Through 10-09-1997",

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TY - JOUR

T1 - Simulation study of epicardial action potential under normal and ischemic conditions

AU - Torres, V.

AU - Ferrero, J. M.

AU - Monserrat, M.

AU - Saiz, J.

AU - Ferrero, J. M.

AU - Thakor, N. V.

PY - 1997

Y1 - 1997

N2 - A computer model has been used to simulate the effects of activation of the ATP sensitive K+ channels on the action potential morphology and duration of canine-type epicardial myocytes. Simulations were based on a modified version of the Luo-Rudy mammalian action potential model. Our formulation of IKATP and the transient outward current (Ito) were included in this model. Our results show that the same fraction of open K-ATP channels has a more pronounced effect in epicardium than in endocardium. We conclude that the presence of a prominent outward current in epicardial but not in endocardial myocytes increases the APD reduction produced by the activation of the K-ATP channels and thus contributes to the dispersion of APD observed under ischemic conditions.

AB - A computer model has been used to simulate the effects of activation of the ATP sensitive K+ channels on the action potential morphology and duration of canine-type epicardial myocytes. Simulations were based on a modified version of the Luo-Rudy mammalian action potential model. Our formulation of IKATP and the transient outward current (Ito) were included in this model. Our results show that the same fraction of open K-ATP channels has a more pronounced effect in epicardium than in endocardium. We conclude that the presence of a prominent outward current in epicardial but not in endocardial myocytes increases the APD reduction produced by the activation of the K-ATP channels and thus contributes to the dispersion of APD observed under ischemic conditions.

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M3 - Conference article

AN - SCOPUS:0031363177

SN - 0276-6574

SP - 501

EP - 504

JO - Computers in cardiology

JF - Computers in cardiology

T2 - Proceedings of the 1997 24th Annual Meeting on Computers in Cardiology

Y2 - 7 September 1997 through 10 September 1997

ER -

Simulation study of epicardial action potential under normal and ischemic conditions

Abstract

ASJC Scopus subject areas

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