Simulation study of epicardial action potential under normal and ischemic conditions

V. Torres, J. M. Ferrero, M. Monserrat, J. Saiz, J. M. Ferrero, N. V. Thakor

Research output: Contribution to journalConference articlepeer-review

1 Scopus citations


A computer model has been used to simulate the effects of activation of the ATP sensitive K+ channels on the action potential morphology and duration of canine-type epicardial myocytes. Simulations were based on a modified version of the Luo-Rudy mammalian action potential model. Our formulation of IKATP and the transient outward current (Ito) were included in this model. Our results show that the same fraction of open K-ATP channels has a more pronounced effect in epicardium than in endocardium. We conclude that the presence of a prominent outward current in epicardial but not in endocardial myocytes increases the APD reduction produced by the activation of the K-ATP channels and thus contributes to the dispersion of APD observed under ischemic conditions.

Original languageEnglish (US)
Pages (from-to)501-504
Number of pages4
JournalComputers in cardiology
StatePublished - 1997
Externally publishedYes
EventProceedings of the 1997 24th Annual Meeting on Computers in Cardiology - Lund, Sweden
Duration: Sep 7 1997Sep 10 1997

ASJC Scopus subject areas

  • Computer Science Applications
  • Cardiology and Cardiovascular Medicine


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