Simulation of triggered activity and abnormal automaticity in ventricular myocytes

J. Saiz, J. M. Ferrero, J. M. Ferrero, L. M. Roa, N. V. Thakor

Research output: Contribution to journalConference articlepeer-review

3 Scopus citations


The goal of this work is to theoretically study the effect of cellular coupling on generation of triggered activity and abnormal automaticity in cardiac ventricular myocytes. We have used a computer model of the ventricular action potential in a system of two cells coupled by a resistance R. With [Ca]i=0.5μM, the spontaneous activity varies from two action potentials followed by three DADs at R=10M Ω to eight action potentials for complete uncoupling. Under EAD conditions, EADs appear on the AP plateau for complete uncoupling, thus provoking lengthening. When the value of R is decreased, the APD becames substantially shortened. However, at a value of R for which the action potential is propagated a prolongation of APD is again produced. Therefore, the coupling resistance may affect triggered activity and abnormal automatically formation.

Original languageEnglish (US)
Pages (from-to)345-348
Number of pages4
JournalComputers in cardiology
StatePublished - 1995
Externally publishedYes
EventProceedings of the 1995 Conference on Computers in Cardiology - Vienna, Austria
Duration: Sep 10 1995Sep 13 1995

ASJC Scopus subject areas

  • Computer Science Applications
  • Cardiology and Cardiovascular Medicine


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