Similarity of synthetic peptide from human tumor to parathyroid hormone in vivo and in vitro

Noboru Horiuchi; Mlchael P. Caulfield; John E. Fisher; Mark E. Goldman; Roberta L. McKee; Jane E. Reagan; Jay J. Levy; Ruth F. Nutt; Sevgi B. Rodan; Timothy L. Schofield; Thomas L. Clemens; Michael Rosenblatt

doi:10.1126/science.3685994

Similarity of synthetic peptide from human tumor to parathyroid hormone in vivo and in vitro

Noboru Horiuchi, Mlchael P. Caulfield, John E. Fisher, Mark E. Goldman, Roberta L. McKee, Jane E. Reagan, Jay J. Levy, Ruth F. Nutt, Sevgi B. Rodan, Timothy L. Schofield, Thomas L. Clemens, Michael Rosenblatt

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Abstract

One mechanism considered responsible for the hypercalcemia that frequently accompanies malignancy is secretion by the tumor of a circulating factor that alters calcium metabolism. The structure of a tumor-secreted peptide was recently determined and found to be partially homologous to parathyroid hormone (PTH). The aminoterminal 1-34 region of the factor was synthesized and evaluated biologically. In vivo it produced hypercalcemia, acted on bone and kidney, and stimulated 1,25-dihydroxyvitamin D₃ formation. In vitro it interacted with PTH receptors and, in some systems, was more potent than PTH. These studies support a long-standing hypothesis regarding pathogenesis of malignancy-associated hypercalcemia.

Original language	English (US)
Pages (from-to)	1566-1568
Number of pages	3
Journal	Science
Volume	238
Issue number	4833
DOIs	https://doi.org/10.1126/science.3685994
State	Published - 1987
Externally published	Yes

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@article{d8fa9a808e634394abf1216ecc0b4a49,

title = "Similarity of synthetic peptide from human tumor to parathyroid hormone in vivo and in vitro",

abstract = "One mechanism considered responsible for the hypercalcemia that frequently accompanies malignancy is secretion by the tumor of a circulating factor that alters calcium metabolism. The structure of a tumor-secreted peptide was recently determined and found to be partially homologous to parathyroid hormone (PTH). The aminoterminal 1-34 region of the factor was synthesized and evaluated biologically. In vivo it produced hypercalcemia, acted on bone and kidney, and stimulated 1,25-dihydroxyvitamin D3 formation. In vitro it interacted with PTH receptors and, in some systems, was more potent than PTH. These studies support a long-standing hypothesis regarding pathogenesis of malignancy-associated hypercalcemia.",

author = "Noboru Horiuchi and Caulfield, {Mlchael P.} and Fisher, {John E.} and Goldman, {Mark E.} and McKee, {Roberta L.} and Reagan, {Jane E.} and Levy, {Jay J.} and Nutt, {Ruth F.} and Rodan, {Sevgi B.} and Schofield, {Timothy L.} and Clemens, {Thomas L.} and Michael Rosenblatt",

year = "1987",

doi = "10.1126/science.3685994",

language = "English (US)",

volume = "238",

pages = "1566--1568",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "4833",

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TY - JOUR

T1 - Similarity of synthetic peptide from human tumor to parathyroid hormone in vivo and in vitro

AU - Horiuchi, Noboru

AU - Caulfield, Mlchael P.

AU - Fisher, John E.

AU - Goldman, Mark E.

AU - McKee, Roberta L.

AU - Reagan, Jane E.

AU - Levy, Jay J.

AU - Nutt, Ruth F.

AU - Rodan, Sevgi B.

AU - Schofield, Timothy L.

AU - Clemens, Thomas L.

AU - Rosenblatt, Michael

PY - 1987

Y1 - 1987

N2 - One mechanism considered responsible for the hypercalcemia that frequently accompanies malignancy is secretion by the tumor of a circulating factor that alters calcium metabolism. The structure of a tumor-secreted peptide was recently determined and found to be partially homologous to parathyroid hormone (PTH). The aminoterminal 1-34 region of the factor was synthesized and evaluated biologically. In vivo it produced hypercalcemia, acted on bone and kidney, and stimulated 1,25-dihydroxyvitamin D3 formation. In vitro it interacted with PTH receptors and, in some systems, was more potent than PTH. These studies support a long-standing hypothesis regarding pathogenesis of malignancy-associated hypercalcemia.

AB - One mechanism considered responsible for the hypercalcemia that frequently accompanies malignancy is secretion by the tumor of a circulating factor that alters calcium metabolism. The structure of a tumor-secreted peptide was recently determined and found to be partially homologous to parathyroid hormone (PTH). The aminoterminal 1-34 region of the factor was synthesized and evaluated biologically. In vivo it produced hypercalcemia, acted on bone and kidney, and stimulated 1,25-dihydroxyvitamin D3 formation. In vitro it interacted with PTH receptors and, in some systems, was more potent than PTH. These studies support a long-standing hypothesis regarding pathogenesis of malignancy-associated hypercalcemia.

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EP - 1568

JO - Science

JF - Science

IS - 4833

ER -

Similarity of synthetic peptide from human tumor to parathyroid hormone in vivo and in vitro

Abstract

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