Simian virus 40-associated fatal interstitial pneumonia and renal tubular necrosis in a rhesus monkey

W. Douglas Sheffield; John D. Strandberg; Lundy Braun; Keerti Shah; S. S. Kalter

doi:10.1093/infdis/142.4.618

Simian virus 40-associated fatal interstitial pneumonia and renal tubular necrosis in a rhesus monkey

W. Douglas Sheffield, John D. Strandberg, Lundy Braun, Keerti Shah, S. S. Kalter

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Simian virus 40 was isolated from a young adult rhesus monkey dying of naturally acquired interstitial pneumonia and renal tubular necrosis. Light microscopic examination demonstrated basophilic intranuclear inclusions associated with the lesions in the lung and the kidney. These inclusions were positive for antigen of simian virus 40 by immunoperoxidase staining of paraffin sections of affected organs. Electron microscopy revealed characteristic papovavirus particles in these tissues. This study is the first report indicating that simian virus 40 may produce pulmonary and renal disease in its natural host.

Original language	English (US)
Pages (from-to)	618-622
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	142
Issue number	4
DOIs	https://doi.org/10.1093/infdis/142.4.618
State	Published - Oct 1980
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

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10.1093/infdis/142.4.618

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title = "Simian virus 40-associated fatal interstitial pneumonia and renal tubular necrosis in a rhesus monkey",

abstract = "Simian virus 40 was isolated from a young adult rhesus monkey dying of naturally acquired interstitial pneumonia and renal tubular necrosis. Light microscopic examination demonstrated basophilic intranuclear inclusions associated with the lesions in the lung and the kidney. These inclusions were positive for antigen of simian virus 40 by immunoperoxidase staining of paraffin sections of affected organs. Electron microscopy revealed characteristic papovavirus particles in these tissues. This study is the first report indicating that simian virus 40 may produce pulmonary and renal disease in its natural host.",

author = "Sheffield, {W. Douglas} and Strandberg, {John D.} and Lundy Braun and Keerti Shah and Kalter, {S. S.}",

note = "Funding Information: This work was supported by grants no. RR07oo2, RRoo130, and NCA 13478 from the National Institutes of Health (NIH) to The Johns Hopkins University and grants no. RR00361 from the NIH and no. V4/181/38 from the World Health Organization (WHO) to the Southwest Foundation for Research and Education, which serves as the NIH and WHO Collaborating Center for Reference and Research in Simian Viruses.",

year = "1980",

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doi = "10.1093/infdis/142.4.618",

language = "English (US)",

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T1 - Simian virus 40-associated fatal interstitial pneumonia and renal tubular necrosis in a rhesus monkey

AU - Sheffield, W. Douglas

AU - Strandberg, John D.

AU - Braun, Lundy

AU - Shah, Keerti

AU - Kalter, S. S.

N1 - Funding Information: This work was supported by grants no. RR07oo2, RRoo130, and NCA 13478 from the National Institutes of Health (NIH) to The Johns Hopkins University and grants no. RR00361 from the NIH and no. V4/181/38 from the World Health Organization (WHO) to the Southwest Foundation for Research and Education, which serves as the NIH and WHO Collaborating Center for Reference and Research in Simian Viruses.

PY - 1980/10

Y1 - 1980/10

N2 - Simian virus 40 was isolated from a young adult rhesus monkey dying of naturally acquired interstitial pneumonia and renal tubular necrosis. Light microscopic examination demonstrated basophilic intranuclear inclusions associated with the lesions in the lung and the kidney. These inclusions were positive for antigen of simian virus 40 by immunoperoxidase staining of paraffin sections of affected organs. Electron microscopy revealed characteristic papovavirus particles in these tissues. This study is the first report indicating that simian virus 40 may produce pulmonary and renal disease in its natural host.

AB - Simian virus 40 was isolated from a young adult rhesus monkey dying of naturally acquired interstitial pneumonia and renal tubular necrosis. Light microscopic examination demonstrated basophilic intranuclear inclusions associated with the lesions in the lung and the kidney. These inclusions were positive for antigen of simian virus 40 by immunoperoxidase staining of paraffin sections of affected organs. Electron microscopy revealed characteristic papovavirus particles in these tissues. This study is the first report indicating that simian virus 40 may produce pulmonary and renal disease in its natural host.

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Simian virus 40-associated fatal interstitial pneumonia and renal tubular necrosis in a rhesus monkey

Abstract

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