Silicon tissue assays in nonaugmented cadaveric patients: Is there a baseline level?

Gregory R.D. Evans, Sheri Slezak, Michael Rieters, Gregory M. Bercowy

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Microscopic silicone in various tissues in the bodies of females with breast implants has led to the possible incrimination of these implants with connective-tissue disorders. Current technology precludes accurate silicone measurements, but all compounds containing the element silicon (which would include silicone) may be measured accurately. Direct positive correlations of silicon assays with silicone measured levels were confirmed by adding known amounts of silicone oil as a control. With the ubiquitous nature of organosilicons (food containers, syringes, etc.), we hypothesized that baseline silicon levels could be detected in tissues of cadavers without silicone breast augmentation. Ten cadavers were examined. Tissue samples were derived from subcutaneous fat, nipple, breast tissue, liver, spleen, and axillary nodes. Nine of 10 cadavers had silicon levels in various tissues. Measurements were performed by direct current atomic emission spectroscopy. The baseline data were compared with those from four augmented patients who underwent capsulectomies and implant removal. Silicon levels were fivefold higher in the augmented patients than in the nonaugmented cadavers. No difference in levels was noted if the patient had an intact or ruptured implant a n d /o r was symptomatic versus asymptomatic for immunologic disease. This study was designed to measure baseline silicon levels in the normal population. It also has established an accurate level of measurement of tissue silicone.

Original languageEnglish (US)
Pages (from-to)1117-1122
Number of pages6
JournalPlastic and reconstructive surgery
Issue number6
StatePublished - May 1994
Externally publishedYes

ASJC Scopus subject areas

  • Surgery


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