Silicon nanoparticles as hyperpolarized magnetic resonance imaging agents

Jacob W. Aptekar; Maja C. Cassidy; Alexander C. Johnson; Robert A. Barton; Menyoung Lee; Alexander C. Ogier; Chinh Vo; Melis N. Anahtar; Yin Ren; Sangeeta N. Bhatia; Chandrasekhar Ramanathan; David G. Cory; Alison L. Hill; Ross W. Mair; Matthew S. Rosen; Ronald L. Walsworth; Charles M. Marcus

doi:10.1021/nn900996p

Silicon nanoparticles as hyperpolarized magnetic resonance imaging agents

Jacob W. Aptekar, Maja C. Cassidy, Alexander C. Johnson, Robert A. Barton, Menyoung Lee, Alexander C. Ogier, Chinh Vo, Melis N. Anahtar, Yin Ren, Sangeeta N. Bhatia, Chandrasekhar Ramanathan, David G. Cory, Alison L. Hill, Ross W. Mair, Matthew S. Rosen, Ronald L. Walsworth, Charles M. Marcus

Research output: Contribution to journal › Article › peer-review

77 Scopus citations

Abstract

Magnetic resonance imaging of hyperpolarized nuclei provides high image contrast with little or no background signal. To date, in vivo applications of prehyperpolarized materials have been limited by relatively short nuclear spin relaxation times. Here, we investigate silicon nanoparticles as a new type of hyperpolarized magnetic resonance imaging agent. Nuclear spin relaxation times for a variety of Si nanoparticles are found to be remarkably long, ranging from many minutes to hours at room temperature, allowing hyperpolarized nanoparticles to be transported, administered, and imaged on practical time scales. Additionally, we demonstrate that Si nanoparticles can be surface functionalized using techniques common to other biologically targeted nanoparticle systems. These results suggest that Si nanoparticles can be used as a targetable, hyperpolarized magnetic resonance imaging agent with a large range of potential applications.

Original language	English (US)
Pages (from-to)	4003-4008
Number of pages	6
Journal	ACS Nano
Volume	3
Issue number	12
DOIs	https://doi.org/10.1021/nn900996p
State	Published - Dec 22 2009
Externally published	Yes

Keywords

Contrast agent
Functionalized nanoparticle
Hyperpolarized
Magnetic resonance imaging (MRI)
Molecular imaging
Nuclear magnetic resonance
Nuclear spin relaxation
Silicon nanoparticle

ASJC Scopus subject areas

General Materials Science
General Engineering
General Physics and Astronomy

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10.1021/nn900996p

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Aptekar, J. W., Cassidy, M. C., Johnson, A. C., Barton, R. A., Lee, M., Ogier, A. C., Vo, C., Anahtar, M. N., Ren, Y., Bhatia, S. N., Ramanathan, C., Cory, D. G., Hill, A. L., Mair, R. W., Rosen, M. S., Walsworth, R. L., & Marcus, C. M. (2009). Silicon nanoparticles as hyperpolarized magnetic resonance imaging agents. ACS Nano, 3(12), 4003-4008. https://doi.org/10.1021/nn900996p

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title = "Silicon nanoparticles as hyperpolarized magnetic resonance imaging agents",

abstract = "Magnetic resonance imaging of hyperpolarized nuclei provides high image contrast with little or no background signal. To date, in vivo applications of prehyperpolarized materials have been limited by relatively short nuclear spin relaxation times. Here, we investigate silicon nanoparticles as a new type of hyperpolarized magnetic resonance imaging agent. Nuclear spin relaxation times for a variety of Si nanoparticles are found to be remarkably long, ranging from many minutes to hours at room temperature, allowing hyperpolarized nanoparticles to be transported, administered, and imaged on practical time scales. Additionally, we demonstrate that Si nanoparticles can be surface functionalized using techniques common to other biologically targeted nanoparticle systems. These results suggest that Si nanoparticles can be used as a targetable, hyperpolarized magnetic resonance imaging agent with a large range of potential applications.",

keywords = "Contrast agent, Functionalized nanoparticle, Hyperpolarized, Magnetic resonance imaging (MRI), Molecular imaging, Nuclear magnetic resonance, Nuclear spin relaxation, Silicon nanoparticle",

author = "Aptekar, {Jacob W.} and Cassidy, {Maja C.} and Johnson, {Alexander C.} and Barton, {Robert A.} and Menyoung Lee and Ogier, {Alexander C.} and Chinh Vo and Anahtar, {Melis N.} and Yin Ren and Bhatia, {Sangeeta N.} and Chandrasekhar Ramanathan and Cory, {David G.} and Hill, {Alison L.} and Mair, {Ross W.} and Rosen, {Matthew S.} and Walsworth, {Ronald L.} and Marcus, {Charles M.}",

year = "2009",

month = dec,

day = "22",

doi = "10.1021/nn900996p",

language = "English (US)",

volume = "3",

pages = "4003--4008",

journal = "ACS Nano",

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T1 - Silicon nanoparticles as hyperpolarized magnetic resonance imaging agents

AU - Aptekar, Jacob W.

AU - Cassidy, Maja C.

AU - Johnson, Alexander C.

AU - Barton, Robert A.

AU - Lee, Menyoung

AU - Ogier, Alexander C.

AU - Vo, Chinh

AU - Anahtar, Melis N.

AU - Ren, Yin

AU - Bhatia, Sangeeta N.

AU - Ramanathan, Chandrasekhar

AU - Cory, David G.

AU - Hill, Alison L.

AU - Mair, Ross W.

AU - Rosen, Matthew S.

AU - Walsworth, Ronald L.

AU - Marcus, Charles M.

PY - 2009/12/22

Y1 - 2009/12/22

N2 - Magnetic resonance imaging of hyperpolarized nuclei provides high image contrast with little or no background signal. To date, in vivo applications of prehyperpolarized materials have been limited by relatively short nuclear spin relaxation times. Here, we investigate silicon nanoparticles as a new type of hyperpolarized magnetic resonance imaging agent. Nuclear spin relaxation times for a variety of Si nanoparticles are found to be remarkably long, ranging from many minutes to hours at room temperature, allowing hyperpolarized nanoparticles to be transported, administered, and imaged on practical time scales. Additionally, we demonstrate that Si nanoparticles can be surface functionalized using techniques common to other biologically targeted nanoparticle systems. These results suggest that Si nanoparticles can be used as a targetable, hyperpolarized magnetic resonance imaging agent with a large range of potential applications.

AB - Magnetic resonance imaging of hyperpolarized nuclei provides high image contrast with little or no background signal. To date, in vivo applications of prehyperpolarized materials have been limited by relatively short nuclear spin relaxation times. Here, we investigate silicon nanoparticles as a new type of hyperpolarized magnetic resonance imaging agent. Nuclear spin relaxation times for a variety of Si nanoparticles are found to be remarkably long, ranging from many minutes to hours at room temperature, allowing hyperpolarized nanoparticles to be transported, administered, and imaged on practical time scales. Additionally, we demonstrate that Si nanoparticles can be surface functionalized using techniques common to other biologically targeted nanoparticle systems. These results suggest that Si nanoparticles can be used as a targetable, hyperpolarized magnetic resonance imaging agent with a large range of potential applications.

KW - Contrast agent

KW - Functionalized nanoparticle

KW - Hyperpolarized

KW - Magnetic resonance imaging (MRI)

KW - Molecular imaging

KW - Nuclear magnetic resonance

KW - Nuclear spin relaxation

KW - Silicon nanoparticle

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Silicon nanoparticles as hyperpolarized magnetic resonance imaging agents

Abstract

Keywords

ASJC Scopus subject areas

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