Signet-ring Stromal Tumor of the Ovary: Clinicopathologic Analysis and Comparison with Krukenberg Tumor

Russell Vang, Sílvia Bagué, Fattaneh A. Tavassoli, Jaime Prat

Research output: Contribution to journalArticlepeer-review

59 Scopus citations


Signet-ring stromal tumor is a rare ovarian neoplasm that can mimic Krukenberg tumor because of the presence of signet-ring cells in both tumors. The clinicopathologic features of three signet-ring stromal tumors, one of which has been previously reported, were analyzed and compared with 10 Krukenberg tumors. Patients with signet-ring stromal tumor ranged in age from 34 to 41 years (mean: 36.7 years). All signet-ring stromal tumors were unilateral and stage IA, whereas 60% and 40% of Krukenberg tumors were bilateral or associated with extraovarian tumor, respectively. The signet-ring stromal tumors were devoid of epithelial differentiation (glands, nests, cords), whereas all of the Krukenberg tumors contained these epithelial structures at least focally. In contrast to signet-ring stromal tumors, the signet-ring cells of Krukenberg tumors were positive for periodic acid-Schiff with diastase and cytokeratins but negative for vimentin. The patients with signet-ring stromal tumors were alive without disease at follow-up interval of 1 month to 17.4 years (mean: 7.4 years). In summary, signet-ring stromal tumor is a rare, benign, ovarian tumor that may be mistaken for Krukenberg tumor. Although the combination of operative and histopathologic findings allow their distinction, histochemical and immunohistochemical stains may also be useful.

Original languageEnglish (US)
Pages (from-to)45-51
Number of pages7
JournalInternational Journal of Gynecological Pathology
Issue number1
StatePublished - Jan 1 2004
Externally publishedYes


  • Krukenberg tumor
  • Metastatic adenocarcinoma
  • Ovary
  • Signet-ring cells
  • Signet-ring stromal tumor

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Obstetrics and Gynecology


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