TY - JOUR
T1 - Signal transduction underlying growth cone guidance by diffusible factors
AU - Song, Hong Jun
AU - Poo, Mu Ming
PY - 1999/6
Y1 - 1999/6
N2 - Many diffusible axon guidance cues and their receptors have been identified recently. These cues are often found to be bifunctional, acting as attractants or repellents under different circumstances. Studies of cytoplasmic signaling mechanisms have led to the notion that the response of a growth cone to a particular guidance cue depends on the internal state of the neuron, which, in turn, is under the influence of other coincident signals received by the neuron. Furthermore, many diffusible guidance cues appear to share common cytoplasmic signaling pathways.
AB - Many diffusible axon guidance cues and their receptors have been identified recently. These cues are often found to be bifunctional, acting as attractants or repellents under different circumstances. Studies of cytoplasmic signaling mechanisms have led to the notion that the response of a growth cone to a particular guidance cue depends on the internal state of the neuron, which, in turn, is under the influence of other coincident signals received by the neuron. Furthermore, many diffusible guidance cues appear to share common cytoplasmic signaling pathways.
UR - http://www.scopus.com/inward/record.url?scp=0033152924&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033152924&partnerID=8YFLogxK
U2 - 10.1016/S0959-4388(99)80052-X
DO - 10.1016/S0959-4388(99)80052-X
M3 - Article
C2 - 10395576
AN - SCOPUS:0033152924
SN - 0959-4388
VL - 9
SP - 355
EP - 363
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
IS - 3
ER -