Signal transduction pathways in apoptosis

David J. McConkey, Sten Orrenius

Research output: Contribution to journalReview articlepeer-review

96 Scopus citations


Emerging evidence indicates that apoptosis is regulated by some of the same signal transduction pathways previously implicated in other physiological cellular responses, including alterations in intracellular Ca2+ compartmentalization, activation of protein kinases and phosphatases, alterations in pH and oxidative stress. Interestingly, signals that promote apoptosis in one model can suppress cell death in another, indicating that cellular responses are determined by the intrinsic programming of the cell in question. This review will summarize current knowledge of the signal transduction pathways regulating apoptosis and discuss how they may be coupled to components of the molecular machinery for cell death.

Original languageEnglish (US)
Pages (from-to)619-631
Number of pages13
JournalStem Cells
Issue number6
StatePublished - Nov 1996
Externally publishedYes


  • Apotosis
  • BCL-2
  • Calcium
  • Ceramide
  • Cyclin-dependent kinases
  • Endonuclease
  • PKC
  • Protease
  • cAMP

ASJC Scopus subject areas

  • Molecular Medicine
  • Developmental Biology
  • Cell Biology


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