Sigma opioid receptor; SKF-10,047 update

N. Khazan, G. A. Young, E. E. El-Fakahany, O. Hong, D. Calligaro

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


We found that (-)-SKF-10,047 blocks EEG and behavioral effects of morphine in the naive rat, precipitates withdrawal in morphine-dependent rats, produces physical dependence as evidenced by naloxone-induced withdrawal, and displaces [3H] dihydromorphine from brain homogenates. (+)-SKF- 10,047 did not produce dependence upon chronic treatment, and it did not displace [3H] dihydromorphine from brain homogenates. Such pharmacodynamic dissociation of SKF-10,047 effects suggests an association of sigma receptors with psychotogenic, but not opioid characteristics. The latter are most likely mediated by mu or kappa receptors.

Original languageEnglish (US)
Pages (from-to)339-340
Number of pages2
Issue number4-6
StatePublished - Feb 1985
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology
  • Neurology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience


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