Siblings with ischemic stroke study: Results of a genome-wide scan for stroke loci

James F. Meschia, Michael Nalls, Mar Matarin, Thomas G. Brott, Robert D. Brown, John Hardy, Brett Kissela, Stephen S. Rich, Andrew Singleton, Dena Hernandez, Luigi Ferrucci, Kerra Pearce, Margaret Keller, Bradford B. Worrall

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Background and Purpose-Ischemic stroke has a strong familial component to risk. The Siblings With Ischemic Stroke Study (SWISS) is a genome-wide, family-based analysis that included use of imputed genotypes. The Siblings With Ischemic Stroke Study was conducted to examine the associations between single-nucleotide polymorphisms (SNPs) and risk of stroke and stroke subtypes within pairs. Methods-The Siblings With Ischemic Stroke Study enrolled 312 probands with ischemic stroke from 70 US and Canadian centers. Affected siblings were ascertained by centers and confirmed by central record review; unaffected siblings were ascertained by telephone contact. Ischemic stroke was subtyped according to Trial of Org 10172 in Acute Stroke Treatment criteria. Genotyping was performed with an Illumina 610 quad array (probands) and an Illumina linkage V array (affected siblings). SNPs were imputed by using 1000 Genomes Project data and MACH software. Family-based association analyses were conducted by using the sibling transmission-disequilibrium test. RESULTS-: For all pairs, the correlation of age at stroke within pairs of affected siblings was r=0.83 (95% CI, 0.78-0.86; P

Original languageEnglish (US)
Pages (from-to)2726-2732
Number of pages7
Issue number10
StatePublished - Oct 2011
Externally publishedYes


  • cerebral infarct
  • genetics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialized Nursing


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