Abstract
Background: C-terminal SPAK fragments are found in kidney medulla.
Results:Weidentified Dnpep as the protease responsible for SPAK cleavage, identified the sites of cleavage, and showed unusual preference for α helices.
Conclusion: C-terminal SPAK fragments originate from Dnpep-mediated proteolytic cleavage.
Significance: SPAK and its cleavage are significant for the regulation of renal Na+ reabsorption and control of blood pressure.
Original language | English (US) |
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Pages (from-to) | 29273-29284 |
Number of pages | 12 |
Journal | Journal of Biological Chemistry |
Volume | 289 |
Issue number | 42 |
DOIs | |
State | Published - Oct 17 2014 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology