Short echo time proton mr spectroscopic imaging

Stefan Posse, Bernhard Schuknecht, Mary E. Smith, Peter C.M. Van Zijl, Norbert Herschkowitz, Chrit T.W. Moonen

Research output: Contribution to journalArticlepeer-review

76 Scopus citations


Proton spectroscopic imaging at short TEs (20-30 ms) in human brain requires volume preselection inside the brain to suppress overwhelming lipid and water signals from surrounding tissue. In this article we discuss limitations of conventional volume preselection using stimulated echoes that lead to spectral contamination from surrounding tissue. Improved volume preselection was obtained by adding a complete outer volume suppression (presaturation). The performance of the method is illustrated on normal volunteers and on clinical cases with brain tumors and multiple sclerosis (MS) plaques. In normal human brain, we detected resonances with short T2 values and complex J-coupling, including rather broad methyl/methylene resonances in the chemical shift range between 0 and 2 ppm. Spectroscopic images obtained on patients with intracranial tumors and on one patient with several MS plaques demonstrate the possibility of detecting regional distributions of increased methyl/ methylene resonances between 0 and 2 ppm in brain lesions.

Original languageEnglish (US)
Pages (from-to)1-14
Number of pages14
JournalJournal of computer assisted tomography
Issue number1
StatePublished - Jan 1 1993


  • Brain
  • Magnetic resonance imaging
  • Multiple sclerosis
  • Neoplasms
  • Spectroscopy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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