Shedding light on the dark cancer genomes: Long noncoding RNAs as novel biomarkers and potential therapeutic targets for cancer

Lin Zhang, Dan Peng, Anil K. Sood, Chi V. Dang, Xiaomin Zhong

Research output: Contribution to journalReview articlepeer-review

Abstract

Recently there have been explosive discoveries of new long noncoding RNAs (lncRNA) obtained by progress in the technology of second-generation sequencing. Genome scale analysis of transcriptome, in conjunction with studies on chromatin modifications at the epigenetic level, identified lncRNAs as a novel type of noncoding transcripts whose length is longer than 200 nucleotides. These transcripts are later found as major participants in various physiologic processes and diseases, especially in human cancers. LncRNAs have been found to function as novel types of oncogenes and tumor suppressors during cancer progression through various mechanisms, which endow them with the potential of serving as reliable biomarkers and novel therapeutic targets for cancers.

Original languageEnglish (US)
Pages (from-to)1816-1823
Number of pages8
JournalMolecular cancer therapeutics
Volume17
Issue number9
DOIs
StatePublished - Sep 2018
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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